Matrixyl Research Peptide
This is a peptide of five residues, with a long fatty chain joined to one end.
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Research Use Only · Not for human or veterinary consumption.
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Certificates of Analysis
Every batch is tested by an independent laboratory before release.
Verify Batch. Lot-level COA, Batch DF/MAT/062026. Check the batch number printed on your vial against the certificate below, which reports the tests run on it.
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What is Matrixyl?
This is a peptide of five residues, with a long fatty chain joined to one end. Its cosmetic-ingredient name is palmitoyl pentapeptide-4. It is also written Pal-KTTKS. Across the beauty trade it is sold as Matrixyl. The five residues come from the end section of human type I procollagen, the precursor chain that is trimmed to make collagen. That end section is cut off outside the cell, so it is not part of finished collagen. The fatty tail is not decoration. The bare peptide is water-loving and stays on the surface of skin. The greasy end changes how it behaves there. KTTKS on its own is a separate molecule with its own separate research.
Product information reviewed by Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer · Reviewed
Matrixyl Research & Reference
What Matrixyl does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
Matrixyl Batch Results
Batch DF/MAT/062026
- Laboratory
- Kovera Labs
- Certified
- August 13, 2026
- Sample
- 10 mg vial
- Report
- KVR-2026-ED87EC
An independent laboratory, Kovera Labs, tested a sample from this batch. These are the results on its certificate.
Purity
Pass99.498%
RP-HPLC, C18 column, 214 nm
Identity
PassConfirmed
LC-MS
Purity is an HPLC figure: the main peak’s share of everything the detector recorded at one wavelength. It’s not a weight. What a purity figure counts →
Check it with the lab. Kovera Labs’ verification page looks a certificate up by its report number. Product, batch, date and results should match this page.
Chromatogram
RP-HPLC · C18 · DAD 214 nm
Frequently Asked Questions
Is Matrixyl third-party tested for purity?+−
Yes. Every batch of Matrixyl is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
Can I see the Certificate of Analysis before buying?+−
Yes. The Certificate of Analysis for the batch currently in stock can be viewed and downloaded directly on this page, before you place an order. Each certificate states the batch number, the measured purity, and the date of analysis, and can be verified independently with the issuing laboratory using the report number it carries.
What does "Research Use Only" mean?+−
It means Matrixyl is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. Matrixyl is legal to purchase in the United States for in vitro and non-clinical laboratory research. In the United States, cosmetic products and ingredients other than color additives do not require FDA approval before going on the market. No approved drug application names palmitoyl pentapeptide-4 as an active ingredient. This material is supplied for laboratory research only and is not for human consumption. Matrixyl is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is Matrixyl shipped and stored?+−
Matrixyl ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
What is the difference between palmitoyl pentapeptide-4 and KTTKS?+−
KTTKS is the unmodified five-residue peptide. Palmitoyl pentapeptide-4 is the same five residues carrying a sixteen-carbon palmitoyl chain. In one published comparison in hairless mouse skin, the palmitoylated form was more stable and was measured in all three skin layers while the unmodified peptide was not detected in any of them; neither passed through full-thickness skin. The two are catalogued and studied separately.
How much published research is there on this compound?+−
PubMed indexes roughly 15 records under Pal-KTTKS and 13 under Matrixyl, with heavy overlap between them. The Matrixyl research article states what each primary study it cites actually measured.
Dermal Peptide Research
Related Compounds
>99%
>99%
>99%
99%From the blog
Background and context on this compound.
Reviewed for scientific accuracy
Dr. Martina Rossi, PhD
PhD, Université Grenoble Alpes · Scientific Contributor and Reviewer
Dr. Rossi's doctoral research at Université Grenoble Alpes examined the vascular functions of bone morphogenetic proteins. Her peer-reviewed work spans cell and molecular biology, vascular biology, and gene therapy, in journals including Cardiovascular Research, Scientific Reports, and Brain Sciences. She reviews Pure Peptides' product, reference, and research pages for scientific accuracy against the sources they cite.