Matrixyl (CAS 214047-00-4), also known as Palmitoyl Pentapeptide-4 or Pal-KTTKS, is a synthetic lipopeptide with a molecular weight of 802.06 g/mol. Its structure consists of the pentapeptide sequence Lys-Thr-Thr-Lys-Ser, corresponding to a fragment of type I procollagen, conjugated to a palmitoyl (C16 fatty acid) chain at the N-terminus. The KTTKS sequence was identified through systematic screening of procollagen-derived peptide fragments as a matrikine, a small peptide derived from extracellular matrix proteins that signals back to cells to modulate matrix biology. Produced via solid-phase peptide synthesis with subsequent N-terminal palmitoylation, Matrixyl is associated with collagen biosynthesis and dermal matrix remodelling pathways in preclinical dermatological research.

Matrixyl is one of the most studied matrikine-based lipopeptides in preclinical and cosmeceutical dermatology research. In vitro studies have documented that the parent KTTKS pentapeptide stimulates the production of collagen (types I and III) and fibronectin in cultured fibroblasts, establishing the sequence as a matrikine signal for extracellular matrix synthesis [1]. Structure-activity research has examined the role of the palmitoyl chain in cellular interaction and the contribution of the lipid modification to the compound’s observed activity in cell culture models, documenting that the palmitoylated peptide amphiphile C16-KTTKS self-assembles into nanotape structures and stimulates collagen synthesis in human dermal fibroblast culture, characterising the lipid-conjugated form of the KTTKS matrikine as the basis for its activity as a topically relevant peptide active [2], making Matrixyl a key reference compound in dermatological and extracellular-matrix research examining lipid-conjugated matrikine peptides and procollagen-derived signal sequences in preclinical models.

Matrixyl is manufactured in a cGMP compliant, ISO9001 certified laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

View credentials →