Snap-8 (CAS 868844-74-0), also known as Acetyl Octapeptide-3, is a synthetic octapeptide with a molecular weight of 1075.16 g/mo. Defined by the amino acid sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, Snap-8 is a truncated analogue of the 25-amino acid synaptosomal-associated protein SNAP-25, which forms part of the SNARE complex involved in vesicular neurotransmitter release. The acetylated N-terminus and amidated C-terminus confer resistance to exopeptidase degradation. Produced via solid-phase peptide synthesis, Acetyl Octapeptide-3 is associated with SNARE complex assembly and vesicular fusion signalling pathways in preclinical neuromuscular junction research.

Snap-8 has been investigated in preclinical neuroscience and dermatological research as a peptide designed to modulate SNARE-mediated vesicular fusion. The SNARE complex, comprising SNAP-25, syntaxin, and VAMP/synaptobrevin, mediates the calcium-dependent fusion of synaptic vesicles with the presynaptic membrane, and competitive disruption of this assembly process has been the subject of structure-activity research. In vitro studies have documented that synthetic peptides patterned after the N-terminal domain of SNAP-25 inhibit SNARE complex assembly and reduce regulated exocytosis, with inhibitory activity correlating with the peptides’ propensity to adopt an alpha-helical secondary structure [1]. Cell culture studies in neuronal and neuromuscular preparations have examined vesicular exocytosis dynamics following exposure to SNAP-25-derived peptides, documenting that the related hexapeptide Argireline, to which Snap-8 is structurally related as a longer analogue of the same SNAP-25 N-terminal sequence, inhibits Ca²⁺-dependent neurotransmitter release through interference with the formation and stability of the SNARE complex required to drive vesicular fusion [2], making Snap-8 a reference compound in neuroscience and dermatological research examining SNAP-25-derived peptide modulation of SNARE-mediated vesicular fusion in preclinical models.

Snap-8 is manufactured in a cGMP compliant, ISO9001 certified laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

View credentials →