Buy NAD+ Research Nucleotide
Supplied as a lyophilised powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.
Buy NAD+ Research Nucleotide
Supplied as a lyophilised powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA on Request
Every batch
Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA on Request
Every batch
Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
What is NAD+?
NAD+ is a coenzyme found in every living cell, essential for turning nutrients into energy and for the activity of repair and signaling enzymes such as sirtuins and PARPs. It is studied in laboratory and animal research for its effects on metabolism, brain and heart-cell signaling. NAD+ is a nucleotide, not a peptide.
- A core energy coenzyme involved in turning nutrients into cellular energy
- Required by sirtuin enzymes that regulate DNA repair and gene activity
- Also required by PARP repair enzymes and CD38 signaling
- Studied in animal research on metabolism, brain and heart-cell signaling (a nucleotide, not a peptide)
For research use only. Not approved for human therapeutic use.
NAD+ (CAS 53-84-9), formally designated Nicotinamide Adenine Dinucleotide (oxidised form), is a dinucleotide coenzyme with the molecular formula C21H27N7O14P2 and a molecular weight of 663.43 g/mol. Unlike the peptide compounds in this catalogue, NAD+ is a pyridine nucleotide consisting of two nucleotides, nicotinamide mononucleotide (NMN) and adenosine monophosphate (AMP), joined by a pyrophosphate bond. Its structure features a nicotinamide ring capable of accepting a hydride ion (H-) to form the reduced form NADH, a redox transition central to its role as an electron carrier. NAD+ is produced via chemical synthesis and is one of the most extensively studied coenzymes in preclinical metabolic and ageing research.
NAD+ is a coenzyme required by over 500 enzymatic reactions and acting as a co-substrate for three major classes of signalling enzymes: sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and cyclic ADP-ribose synthases (CD38/CD157). Published in vitro studies have shown that the silencing and longevity protein Sir2 deacetylates histone H3 at lysines 9 and 14 in a strictly NAD+-dependent reaction, thereby directly linking the cellular NAD+ pool to protein-deacetylation activity [1]. In vivo rodent studies have shown that age-related declines in tissue NAD+ disrupt nuclear–mitochondrial communication, while restoring NAD+ levels can restore mitochondrial function in aged mice [2], and that restoring NAD+ salvage pathway flux can alter metabolic outcomes, with nicotinamide mononucleotide ameliorating glucose intolerance and increasing insulin sensitivity in diet- and age-induced diabetic mice [3], making NAD+ a reference coenzyme in preclinical metabolic and ageing research examining sirtuin- and PARP-mediated NAD+ consumption and age-dependent NAD+ decline in rodent models.
NAD+ is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.
Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.
References
Scientific Review
Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer
Reviewed for scientific accuracy, 14 June 2026
Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.
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Frequently Asked Questions
Related Compounds
ACE-031
Mol. Wt.
~60,000 g/mol (60 kDa)
Purity
≥98%
CAS No.
N/A (recombinant fusion protein)
GDF-8 (Myostatin)
Mol. Wt.
~25,000 g/mol (mature monomer); ~52,000 g/mol (active dimer)
Purity
≥98%
CAS No.
152918-18-8
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Quality Guaranteed
Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis and MSDS available on request.