Buy NAD+ Research Nucleotide

NAD+ (CAS 53-84-9), formally designated Nicotinamide Adenine Dinucleotide (oxidized form), is a dinucleotide coenzyme with the molecular formula C21H27N7O14P2 and a molecular weight of 663.43 g/mol. Unlike the peptide compounds in this catalog, NAD+ is a pyridine nucleotide consisting of two nucleotides, nicotinamide mononucleotide (NMN) and adenosine monophosphate (AMP), joined by a pyrophosphate bond. Its structure features a nicotinamide ring capable of accepting a hydride ion (H-) to form the reduced form NADH, a redox transition central to its role as an electron carrier. NAD+ is produced via chemical synthesis and is one of the most extensively studied coenzymes in preclinical metabolic and aging research.

NAD+ is a coenzyme required by over 500 enzymatic reactions and acting as a co-substrate for three major classes of signaling enzymes: sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and cyclic ADP-ribose synthases (CD38/CD157). Published in vitro studies have shown that the silencing and longevity protein Sir2 deacetylates histone H3 at lysines 9 and 14 in a strictly NAD+-dependent reaction, thereby directly linking the cellular NAD+ pool to protein-deacetylation activity [1]. In vivo rodent studies have shown that age-related declines in tissue NAD+ disrupt nuclear–mitochondrial communication, while restoring NAD+ levels can restore mitochondrial function in aged mice [2], and that restoring NAD+ salvage pathway flux can alter metabolic outcomes, with nicotinamide mononucleotide ameliorating glucose intolerance and increasing insulin sensitivity in diet- and age-induced diabetic mice [3], making NAD+ a reference coenzyme in preclinical metabolic and aging research examining sirtuin- and PARP-mediated NAD+ consumption and age-dependent NAD+ decline in rodent models.

NAD+ is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 11 August 2026

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