Cardiogen, also known by its tetrapeptide designation AEDR (Ala-Glu-Asp-Arg), is a synthetic tetrapeptide bioregulator with a molecular weight of 489.48 g/mol. Developed at the Saint Petersburg Institute of Bioregulation and Gerontology as part of the Khavinson peptide bioregulator series, Cardiogen was designed based on peptide fractions associated with cardiac tissue. Its sequence, Ala-Glu-Asp-Arg, extends the AED core motif shared across the bioregulator series with a C-terminal arginine residue, a basic amino acid containing the guanidinium group. This structural variation within the AED-based tetrapeptide series, where the C-terminal residue defines organ specificity, is a distinctive feature of the Khavinson bioregulator design framework. Produced via solid-phase peptide synthesis, Cardiogen is associated with cardiac tissue gene expression and myocardial signalling pathways.

Cardiogen belongs to the ultra-short peptide bioregulators developed by Professor Vladimir Khavinson. In common with related bioregulator peptides such as Epithalon (AEDG), Pinealon (EDR) and Cortagen (AEDP), Cardiogen has been proposed to exert its biological activity through direct, sequence-selective interaction with DNA rather than conventional cell-surface receptor-mediated signalling. In vitro research using organotypic culture has documented that Cardiogen stimulates the development of myocardial tissue explants, with a measurable effect on tissue growth that differs between preparations from young and old rats [1]. At the level of the aging cardiovascular system, peptide bioregulators of this class have been reviewed in the broader context of cellular senescence and inflammaging in cardiovascular tissue [2], making Cardiogen a reference compound in preclinical cardiovascular research examining ultra-short peptide-bioregulator modulation of myocardial tissue development, cardiac signalling, and age-related changes in cardiovascular tissue.

Cardiogen is manufactured in a cGMP compliant, ISO9001 certified laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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