N-Acetyl Epitalon is a synthetic tetrapeptide and acetylated derivative of Epithalon, with an approximate molecular weight of 432 g/mol. Its structure, Ac-Ala-Glu-Asp-Gly, retains the Ala-Glu-Asp-Gly (AEDG) core sequence of the parent compound but incorporates an N-terminal acetyl group designed to confer resistance to aminopeptidase-mediated degradation. This acetylation strategy mirrors the approach used in other N-acetylated peptide derivatives such as N-Acetyl Semax, where N-terminal capping has been shown to extend circulating half-life and alter pharmacokinetic characteristics. Produced via solid-phase peptide synthesis, N-Acetyl Epitalon is associated with the same telomerase-related and pineal signalling pathways as its parent compound Epithalon.

N-Acetyl Epitalon has been investigated in preclinical research as a structurally stabilised variant of the AEDG tetrapeptide, with its N-terminal acetylation representing a deliberate modification to address the known susceptibility of short peptides to rapid enzymatic degradation. In vitro studies examining the telomerase-activating properties of the AEDG tetrapeptide core have characterised Epithalon-mediated induction of telomerase catalytic subunit expression, telomerase activity, and telomere elongation in human somatic cell preparations, establishing telomerase activation as a defined molecular output of the unmodified AEDG sequence in human cell culture models [1]. Preclinical biochemical studies have examined Epitalon (Ala-Glu-Asp-Gly) in relation to peptide-degrading enzyme systems, including its effects on enkephalin-degrading enzymes from human serum and interactions with brain membrane receptor preparations, while broader toxicology studies of biologically active peptides have evaluated their effects in mouse embryonic stem-cell models [2,3], making N-Acetyl Epitalon a key reference compound in peptide bioregulator research examining N-terminal acetylation as a stability-increasing modification in AEDG-series telomerase-activating tetrapeptides.

N-Acetyl Epitalon is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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