Thymogen, also known by its dipeptide designation EW (Glu-Trp), is a synthetic dipeptide bioregulator with a molecular weight of 333.34 g/mol. Defined by the amino acid sequence Glu-Trp (L-Glutamyl-L-Tryptophan), Thymogen is one of several ultra-short synthetic peptides developed at the Saint Petersburg Institute of Bioregulation and Gerontology as minimal-sequence bioregulators of immune function. Its structure pairs an acidic glutamic acid residue with the aromatic indole-containing tryptophan residue, a combination that has been the subject of structure-function investigation in the context of thymic peptide signalling. Produced via solid-phase peptide synthesis.

Thymogen has been investigated in preclinical immunology as a dipeptide bioregulator, with published research characterising a mechanism of action distinct from conventional receptor-mediated signalling. In vitro studies in a human monocyte/macrophage cell line have examined the Glu-Trp dipeptide’s modulation of proliferative activity and inflammatory signalling, documenting effects on MAPK (ERK1/2, JNK) and STAT1/STAT3 phosphorylation and characterising reduced secretion of pro-inflammatory cytokines (including TNF-α, IL-6 and IL-17) as a primary readout of the dipeptide’s interaction with immune cell populations [1]. In vivo rodent studies have examined L-glutamyl-L-tryptophan as an immune-mediated antitumour agent, documenting tumour-growth suppression in mice despite the absence of direct tumour-cell cytotoxicity in culture. The study characterised this activity as dependent on NK/NKT-cell cytolytic function, perforin and IL-12 signalling, consistent with an interaction with innate immune effector mechanisms in controlled preclinical tumour models [2], making Thymogen a key reference compound in thymic-peptide research examining minimal-sequence dipeptide modulation of immune cell signalling in preclinical models.

Thymogen is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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