Buy HEP-1 (Gepon) Research Peptide
Supplied as a lyophilized powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.
Buy HEP-1 (Gepon) Research Peptide
Supplied as a lyophilized powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA Available
Every batch
Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA Available
Every batch
Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
Verify Batch
Lot-level COA, Batch DF/HEP/062026
What is HEP-1 (Gepon)?
HEP-1 (also called Gepon) is a synthetic 14-amino-acid immune-modulating peptide developed in Russia. It acts on toll-like receptors and is studied in laboratory research for its effects on antiviral and anti-inflammatory immune signaling.
- A short synthetic peptide studied for its effects on immune-system signaling
- Studied in laboratory research for antiviral and immune signaling activity
- Investigated for anti-inflammatory effects and activity in wound-repair studies
- Works on the innate immune system through toll-like receptor signaling
For research use only. Not approved for human therapeutic use.
HEP-1 (Gepon) is a synthetic 14-amino-acid peptide, Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu (TEKKRRETVEREKE), corresponding to a region of the central alpha-helical domain of ezrin, a membrane-cytoskeleton linker protein. Developed as an immunomodulator, it has been registered for clinical use in Russia since 2001 under the brand name Gepon, where it is reported to suppress IL-6 and other pro-inflammatory cytokines while supporting antibody responses [1]. In a dextran sulfate sodium-induced murine colitis model, the synthetic peptide reduced pro-inflammatory gene transcription (Il1b, Il6, Nos2) and decreased infiltration of Ly6G+ granulocytes and Ly6C+ monocytes into colon tissue [2]. A small pilot clinical study in HIV-positive patients with chronic hepatitis C also reported reduced viral load following oral HEP-1 administration [3]. Much of the remaining published research on this peptide consists of smaller Russian-language clinical and preclinical studies that have not been independently replicated in large, peer-reviewed Western trials, so its proposed mechanisms and clinical effects should be regarded as preliminary.
References
Scientific Review
Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer
Reviewed for scientific accuracy, 14 June 2026
Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.
What Researchers Say
Sign in to leave a reviewNo reviews yet. Be the first to share your research experience.
Frequently Asked Questions
Research
Khavinson Bioregulators: Investigations on Short Peptide Research
Select Size
Quality Guaranteed
Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis available on this page; MSDS available on request.