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Research Use Only · Not for human or veterinary consumption.
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Certificates of Analysis
Every batch is tested by an independent laboratory before release.
Verify Batch. Lot-level COA, Batch DF/PE2/062026. Check the batch number printed on your vial against the certificate below, which reports the tests run on it.
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What is PE-22-28?
PE-22-28 is a chain of seven amino acids. It was designed from a study of how a longer chain called spadin is broken down in blood. The two fragments that study identified were longer than this one, which was built and tested afterwards. Spadin itself is a seventeen-link chain cut from a larger protein, and it is a different substance with its own separate research. Almost everything below comes from a single published study, and no laboratory unconnected to the one that made the compound has published on it.
Product information reviewed by Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer · Reviewed
PE-22-28 Research & Reference
What PE-22-28 does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
PE-22-28 Batch Results
Batch DF/PE2/062026
- Laboratory
- Kovera Labs
- Certified
- August 13, 2026
- Sample
- 10 mg vial
- Report
- KVR-2026-14EC27
An independent laboratory, Kovera Labs, tested a sample from this batch. These are the results on its certificate.
Purity
Pass99.626%
RP-HPLC, C18 column, 214 nm
Identity
PassConfirmed
LC-MS
Purity is an HPLC figure: the main peak’s share of everything the detector recorded at one wavelength. It’s not a weight. What a purity figure counts →
Check it with the lab. Kovera Labs’ verification page looks a certificate up by its report number. Product, batch, date and results should match this page.
Chromatogram
RP-HPLC · C18 · DAD 214 nm
Frequently Asked Questions
Is PE-22-28 third-party tested for purity?+−
Yes. Every batch of PE-22-28 is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
Can I see the Certificate of Analysis before buying?+−
Yes. The Certificate of Analysis for the batch currently in stock can be viewed and downloaded directly on this page, before you place an order. Each certificate states the batch number, the measured purity, and the date of analysis, and can be verified independently with the issuing laboratory using the report number it carries.
What does "Research Use Only" mean?+−
It means PE-22-28 is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. PE-22-28 is legal to purchase in the United States for in vitro and non-clinical laboratory research. It has no FDA approval and no approved human use. PE-22-28 is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is PE-22-28 shipped and stored?+−
PE-22-28 ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
How much research exists on PE-22-28?+−
Very little. Searching the compound's own name returns a single primary study, from the laboratory that designed it. Two further records carry genuine PE-22-28 data under the alias mini-spadin, and both come from that same laboratory. No independent group has published new data on it, although two reviews from unrelated groups discuss it. A much larger literature exists under the name of its parent peptide, spadin, and studies of spadin itself are not evidence about this compound. The PE-22-28 research article reports what those studies found and states which of their results name this compound rather than a group of related molecules.
Is research on spadin research on PE-22-28?+−
No. Spadin is a 17-residue peptide; PE-22-28 is a seven-residue peptide designed from what remains of spadin after the body breaks it down. In the one study comparing them directly, PE-22-28 blocked the TREK-1 channel at roughly one three-hundredth of spadin's concentration and lasted about three times as long, which is the point of it being a different molecule. Spadin's own findings stay on spadin.
Cognitive & Neuropeptide Research
Related Compounds
>99%
>99%
>99%
>99%
Reviewed for scientific accuracy
Dr. Martina Rossi, PhD
PhD, Université Grenoble Alpes · Scientific Contributor and Reviewer
Dr. Rossi's doctoral research at Université Grenoble Alpes examined the vascular functions of bone morphogenetic proteins. Her peer-reviewed work spans cell and molecular biology, vascular biology, and gene therapy, in journals including Cardiovascular Research, Scientific Reports, and Brain Sciences. She reviews Pure Peptides' product, reference, and research pages for scientific accuracy against the sources they cite.