- Purity
- >99%
- Dispatch
- Dispatched next business day with cold-chain delivery
- Cold chain
- Temperature-controlled packaging from lab to door
- Certificate
- Batch-specific Certificate of Analysis available on this page
Multi-vial Discount Available
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Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
Quality Guaranteed
Every batch is HPLC-tested to >99% purity. Certificate of Analysis available on this page; MSDS available on request.
Verify Batch
Lot-level COA, Batch DF/PE2/062026. Check the batch number printed on your vial against the certificate below, which reports the tests run on it.
What is PE-22-28?
PE-22-28 is a chain of seven amino acids. It was made by studying what happens to a longer chain called spadin as the body breaks it down, and keeping the short piece that still worked. Spadin itself is a seventeen-link chain cut from a larger protein, and it is a different substance with its own separate research. Almost everything below comes from a single published study, and no laboratory unconnected to the one that made the compound has published on it.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
PE-22-28 Research & Reference
What PE-22-28 does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Certificates of Analysis
Every batch is tested by an independent laboratory before release. The certificate covering this batch of PE-22-28, and its safety data sheet, are below as PDFs, so the figures on this page can be checked against the source.
Frequently Asked Questions
Is PE-22-28 independently tested for purity?+−
Yes. Every batch of PE-22-28 is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
Can I see the Certificate of Analysis before buying?+−
Yes. The Certificate of Analysis for the batch currently in stock can be viewed and downloaded directly on this page, before you place an order. Each certificate states the batch number, the measured purity, and the date of analysis, and can be verified independently with the issuing laboratory using the report number it carries.
What does "Research Use Only" mean?+−
It means PE-22-28 is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. PE-22-28 is legal to purchase in the United States for in vitro and non-clinical laboratory research. It has no FDA approval and no approved human use. PE-22-28 is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is PE-22-28 shipped and stored?+−
PE-22-28 ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
How much research exists on PE-22-28?+−
Very little. Searching the compound's own name returns one primary study, from the laboratory that designed it, alongside a review by the same authors. No independent group has published on it. A much larger literature exists under the name of its parent peptide, spadin, and none of that is evidence about this compound. The Published Research tab reports what the one study found and states which of its results name this compound rather than a group of related molecules.
Is research on spadin research on PE-22-28?+−
No. Spadin is a 17-residue peptide; PE-22-28 is a seven-residue peptide designed from what remains of spadin after the body breaks it down. In the one study comparing them directly, PE-22-28 blocked the TREK-1 channel at roughly one three-hundredth of spadin's concentration and lasted about three times as long, which is the point of it being a different molecule. Spadin's own findings stay on spadin.
Related Compounds
>99%
>99%
>99%
>99%
>99%
>99%
>99%
>99%