Buy PE-22-28 Research Peptide

PE-22-28 is a synthetic heptapeptide analog of Spadin with an approximate molecular weight of 773.89 g/mol. It is derived from the 44-amino acid propeptide (PE) of the sortilin receptor and corresponds to a truncated fragment of the 17-amino acid peptide Spadin (PE 12-28), retaining the minimal sequence associated with modulation of the TWIK-related potassium channel-1 (TREK-1). TREK-1 is a two-pore domain potassium channel (K2P2.1) expressed throughout the central nervous system and implicated in the regulation of neuronal excitability. Produced via solid-phase peptide synthesis, PE-22-28 is associated with TREK-1 channel modulation and monoaminergic signaling pathways.

PE-22-28 has been investigated in preclinical neuropharmacology as a minimal-length TREK-1 channel modulator and was developed as a shorter, more metabolically tractable analog retaining the active pharmacophore. In vitro electrophysiology studies have documented that PE-22-28 inhibits TREK-1 currents recorded by whole-cell patch clamp in a TREK-1-expressing HEK cell line, blocking the arachidonic-acid-activated channel with markedly greater potency than the parent peptide, and have characterized it as the shortest Spadin-derived fragment retaining TREK-1 inhibitory activity [1]. In vivo rodent studies have examined the compound in behavioral pharmacology paradigms, documenting that PE-22-28 produced antidepressant-like effects in the forced swim, novelty-suppressed feeding and learned-helplessness paradigms and in a corticosterone-induced depression model, and that a four-day systemic (ip) administration schedule increased hippocampal neurogenesis in vivo, while direct application of PE-22-28 to cultured mouse cortical neurons increased the synaptogenesis marker PSD-95 in vitro [1][2], making PE-22-28 a reference compound in preclinical neuropharmacology research examining Spadin-derived TREK-1 channel modulation and hippocampal neuroplasticity in rodent models.

PE-22-28 is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 11 August 2026

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