Selank (CAS 129954-34-3), also known by its developmental code TP-7, is a synthetic heptapeptide and structural analogue of the naturally occurring immunomodulatory tetrapeptide tuftsin. With the molecular formula C33H57N11O9 and a molecular weight of 751.88 g/mol, Selank is defined by the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, incorporating the tuftsin core (Thr-Lys-Pro-Arg) extended at the C-terminus with a Pro-Gly-Pro stabilising motif. This structural feature is considered relevant to its resistance to proteolytic degradation.

Produced via solid-phase peptide synthesis, TP-7 is associated with GABAergic and monoaminergic signalling pathways in preclinical neuroscience and immunology research.

Selank has been investigated in preclinical research across both neuroactive and immunomodulatory contexts, a profile that reflects its structural derivation from tuftsin, a fragment of immunoglobulin G (IgG) associated with innate immune signalling. Its C-terminal Pro-Gly-Pro extension has been characterised in published structure-activity studies as relevant to central nervous system accessibility and peptide stability. In vitro electrophysiology studies in rat hippocampal CA1 pyramidal neuron preparations have examined Selank’s modulation of spontaneous inhibitory postsynaptic currents, documenting increased GABAergic inhibitory neurotransmission through increases in both amplitude and discharge frequency of spontaneous IPSCs and characterising this GABAergic modulatory profile as a neurophysiological basis of TP-7’s neuroactive properties [1]. In vivo rodent behavioural pharmacology studies have examined TP-7 alongside cytokine expression profiling, documenting that Selank administration modulates pro-inflammatory cytokine under social conflict stress conditions in rodents, characterising the relationship between immunomodulatory peptide signalling and central immune marker dynamics under acute stress challenge [2], making Selank a key reference compound in research examining the intersection of GABAergic neuropharmacology and immunomodulatory peptide signalling.

Selank is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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