Buy DSIP (Delta Sleep-Inducing Peptide) Research Peptide

DSIP (CAS 62568-57-4), also known as Delta Sleep-Inducing Peptide and by the INN Emideltide, is a synthetic nonapeptide with the molecular formula C35H48N10O15 and a molecular weight of 848.81 g/mol. Defined by the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, DSIP is classified as an amphiphilic neuropeptide first isolated from rabbit cerebral venous blood in 1977. The N-terminal tryptophan residue provides a characteristic UV absorbance signature used for laboratory identification. Produced via solid-phase peptide synthesis, Delta Sleep-Inducing Peptide is associated with neuroendocrine and circadian signaling pathways.

DSIP has been extensively investigated across a broad range of preclinical neuroendocrine research contexts. The compound has been identified in both free and bound forms within the hypothalamus, limbic system, pituitary, and peripheral tissues, and has been documented as co-localizing with multiple peptide and non-peptide mediators including ACTH, melanocyte-stimulating hormone (MSH), and thyroid-stimulating hormone (TSH). Studies examining DSIP immunoreactivity in human pituitary tissue preparations have characterized DSIP’s interaction with neuroendocrine cell populations, documenting its co-localisation with corticotropin-like intermediate lobe peptide (CLIP) in anterior pituitary corticotroph cells and residual intermediate lobe cell populations, establishing a neuroendocrine co-expression pattern within hypophyseal tissue [1]. In vivo rodent studies have examined the relationship between endogenous DSIP and sleep architecture following sleep deprivation, with research documenting increases in electroencephalographic slow-wave activity and plasma growth hormone release, with evidence that endogenous DSIP plays a physiological role in slow-wave sleep and sleep-related growth hormone release established through antiserum microinjection studies in rats [2], making DSIP a reference compound in neuropeptide research examining the neuroendocrine and circadian signaling correlates of sleep architecture.

DSIP is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 11 August 2026

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