Buy ADAMAX Research Peptide

ADAMAX, formally designated N-Acetyl Semax-Adamantane, is a synthetic nonapeptide and designer analog of Semax incorporating two pharmacokinetically significant terminal modifications. With the molecular formula C50H69N11O11S and a molecular weight of 1032.23 g/mol, ADAMAX retains the ACTH(4-7)-PGP core sequence of Semax but adds an N-terminal acetyl group and a C-terminal adamantane (tricyclic diamondoid) moiety. The acetyl modification confers resistance to N-terminal aminopeptidase degradation, while the adamantane group, a rigid and highly lipophilic hydrocarbon cage, is considered relevant to metabolic stability and membrane permeability. Produced via solid-phase peptide synthesis, ADAMAX is associated with neurotrophic factor signaling.

ADAMAX has been investigated in preclinical neurobiology as a structurally optimised Semax derivative, with its dual terminal modifications representing a deliberate approach to extending peptide half-life and altering pharmacokinetic properties. The adamantane motif, characterized in medicinal chemistry as a lipophilicity-increasing scaffold, has been incorporated to address the known susceptibility of melanocortin-derived peptides to rapid enzymatic degradation. In vivo studies (intranasal administration in rats) have examined BDNF expression in rat basal forebrain in the context of the ACTH(4-7)-PGP pharmacological profile [1], while in vitro studies in basal forebrain glial cell cultures have documented Semax-mediated induction of both BDNF and NGF expression, characterizing neurotrophic factor induction as a defined signaling output of the ACTH(4-7)-PGP core [2], making ADAMAX a reference compound in melanocortin-derived neuropeptide research examining structurally optimised analogs of the ACTH(4-7)-PGP scaffold. Preclinical pharmacokinetic studies have investigated the penetration of Semax/ACTH(4–7)-PGP into rat blood and brain after intranasal administration, with the peptide undergoing rapid enzymatic degradation into its Pro-Gly-Pro metabolite [3].

ADAMAX is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

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