ADAMAX, formally designated N-Acetyl Semax-Adamantane, is a synthetic nonapeptide and designer analogue of Semax incorporating two pharmacokinetically significant terminal modifications. With the molecular formula C50H69N11O11S and a molecular weight of 1032.23 g/mol, ADAMAX retains the ACTH(4-7)-PGP core sequence of Semax but adds an N-terminal acetyl group and a C-terminal adamantane (tricyclic diamondoid) moiety. The acetyl modification confers resistance to N-terminal aminopeptidase degradation, while the adamantane group, a rigid and highly lipophilic hydrocarbon cage, is considered relevant to metabolic stability and membrane permeability. Produced via solid-phase peptide synthesis, ADAMAX is associated with neurotrophic factor signalling.

ADAMAX has been investigated in preclinical neurobiology as a structurally optimised Semax derivative, with its dual terminal modifications representing a deliberate approach to extending peptide half-life and altering pharmacokinetic properties. The adamantane motif, characterised in medicinal chemistry as a lipophilicity-increasing scaffold, has been incorporated to address the known susceptibility of melanocortin-derived peptides to rapid enzymatic degradation. In vitro studies have examined BDNF and neurotrophic factor expression in the context of the ACTH(4-7)-PGP pharmacological profile, with research documenting Semax-mediated activation of BDNF and NGF expression in rat basal forebrain tissue preparations and characterising neurotrophic factor induction as a defined signalling output of the ACTH(4-7)-PGP core [1,2],making ADAMAX a reference compound in melanocortin-derived neuropeptide research examining structurally optimised analogues of the ACTH(4-7)-PGP scaffold. Preclinical pharmacokinetic studies have investigated the penetration of Semax/ACTH(4–7)-PGP into rat blood and brain after intranasal administration, while comparative degradation studies indicate that Semax is more stable than native ACTH(4–10) against rat blood enzymes [3].

ADAMAX is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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