Buy Colivelin Research Peptide

Colivelin is a synthetic hybrid neuropeptide with a molecular weight of 2,645.30 g/mol, constructed as a fusion of two independently characterized neuroprotective sequences. Its N-terminal domain consists of the nine-amino acid core peptide of activity-dependent neurotrophic factor (ADNF9: Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala), C-terminally fused to AGA-(C8R)HNG17, a potent 17-amino acid derivative of Humanin incorporating stabilizing amino acid substitutions at multiple positions. This chimeric design combines two structurally and mechanistically independent neuroprotective signaling domains within a single peptide chain. Produced via solid-phase peptide synthesis, Colivelin activates two distinct intracellular signaling pathways.

Colivelin is designed hybrid construct combining two independent neuroprotective signaling mechanisms. Published research has characterized the ADNF domain as triggering a Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) cascade and the Humanin-derived domain as signaling through a STAT3-dependent pathway, with both mechanisms contributing to the compound’s neuroprotective activity in neuronal cell preparations. In vitro studies have documented that Colivelin suppresses neuronal cell death induced by overexpressed familial Alzheimer’s disease genes and amyloid-beta at femtomolar concentrations and have characterized this neuroprotection as dependent on both an ADNF-triggered CaMKIV pathway and a Humanin-domain-triggered STAT3 pathway [1][2]. In vivo rodent studies documented that central administration of Colivelin suppressed spatial working memory impairment induced by repetitive amyloid-beta injection and antagonized neuronal loss in the hippocampal CA1 region, while peripheral administration was active in a cholinergic amnesia model, indicating neuroprotective and pro-cognitive activity following both central and peripheral administration [2], making Colivelin a reference compound in preclinical neuroscience research examining rationally designed hybrid neuroprotective peptides and dual-pathway (CaMKIV/STAT3) cytoprotective signaling in preclinical models.

Colivelin is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

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