Buy Semax Research Peptide

Semax (CAS 80714-61-0), also known as ACTH(4-7)-PGP, is a synthetic heptapeptide analog of a fragment of adrenocorticotropic hormone (ACTH). With the molecular formula C37H51N9O10S and a molecular weight of 813.92 g/mol, Semax is defined by the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro, consisting of the ACTH(4-7) tetrapeptide core extended at the C-terminus with a Pro-Gly-Pro tripeptide motif. This structural modification is considered relevant to its metabolic stability and central nervous system accessibility. Produced via solid-phase peptide synthesis, ACTH(4-7)-PGP is associated with neurotrophic factor signaling pathways in preclinical neuroscience research.

Semax has been extensively investigated in preclinical neurobiology as one of the most frequently referenced synthetic melanocortin-derived peptides. The ACTH(4-10) fragment from which it is derived has been the subject of extensive structure-activity research examining the non-endocrine signaling properties of melanocortin peptides independently of their adrenal axis activity. In vivo studies using intranasal administration in rats have investigated Semax’s interaction with brain-derived neurotrophic factor (BDNF) expression, with published research documenting ACTH(4-7)-PGP-mediated activation of BDNF in rat basal forebrain tissue preparations and characterizing the neurotrophic factor response as a basis of Semax’s neurotrophic signaling profile [1]. In vivo rodent studies have examined ACTH(4-7)-PGP in experimental models of cerebral ischemia, with published research documenting Semax’s influence on nitric oxide levels in ischemic rat brain and characterizing neuroprotective effects through NO-mediated signaling under conditions of reduced cerebral perfusion [2], making Semax a key reference compound in melanocortin-derived neuropeptide research across neurotrophic factor signaling and neuroprotection models.

Semax is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

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