Buy PT-141 (Bremelanotide) Research Peptide
Supplied as a lyophilized powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.
Buy PT-141 (Bremelanotide) Research Peptide
Supplied as a lyophilized powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA Available
Every batch
Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA Available
Every batch
Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
Verify Batch
Lot-level COA, Batch DF/PT1/062026
What is PT-141 (Bremelanotide)?
PT-141 (bremelanotide) is a synthetic ring-shaped seven-amino-acid peptide derived from Melanotan II. It acts on melanocortin receptors in the brain (mainly MC3R and MC4R) and is studied in research as a tool for melanocortin-receptor and brain signaling.
- A ring-shaped peptide derived from Melanotan II, shifted toward MC3R and MC4R activity
- Acts on brain melanocortin receptors, studied for downstream brain-circuit signaling
- Studied in receptor research for its melanocortin-receptor selectivity
- Used to study binding and signaling in melanocortin-receptor assays
For research use only. Not approved for human therapeutic use.
PT-141 (CAS 189691-06-3), also known as Bremelanotide, is a synthetic cyclic heptapeptide melanocortin receptor agonist with a molecular weight of 1025.17 g/mol. Its structure, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, features an N-terminal acetylated norleucine residue and a lactam bridge between Asp and Lys forming the characteristic macrocyclic ring. PT-141 was derived from the linear alpha-MSH analog Melanotan II through selective C-terminal modification and retains the His-D-Phe-Arg-Trp pharmacophore core. Produced via solid-phase peptide synthesis, Bremelanotide is primarily associated with melanocortin-3 receptor (MC3R) and melanocortin-4 receptor (MC4R) signaling pathways.
PT-141 has been investigated in preclinical melanocortin receptor pharmacology, where its cyclic structure and receptor selectivity profile have been characterized as the pharmacological basis for its use in studying MC3R and MC4R-mediated central signaling. Unlike the endogenous melanocortin ligands alpha-MSH and ACTH, PT-141 incorporates non-natural amino acid substitutions including norleucine and D-phenylalanine that have been characterized as altering its receptor binding characteristics and metabolic stability. In vivo and clinical pharmacology studies have examined Bremelanotide administration in rats, nonhuman primates, and humans, documenting dose-dependent penile erectile responses and hypothalamic neuronal activation (c-Fos induction) consistent with central MC3R/MC4R-mediated melanocortinergic activity underlying PT-141’s pharmacological effects [1].
PT-141 is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.
Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.
References
Scientific Review
Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer
Reviewed for scientific accuracy, 14 June 2026
Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.
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Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis available on this page; MSDS available on request.