VIP (CAS 37221-79-7), also known as Vasoactive Intestinal Polypeptide, is a synthetic 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. With the molecular formula C147H238N44O42S and a molecular weight of 3326.82 g/mol, VIP features a C-terminal amidation and no disulfide bridges in its standard form. First isolated from porcine small intestine in 1970, Vasoactive Intestinal Polypeptide signals through two class II G protein-coupled receptors, VPAC1 and VPAC2. Produced via solid-phase peptide synthesis.

VIP has been extensively investigated across an exceptionally broad range of preclinical research disciplines, reflecting the widespread distribution of VPAC receptors throughout the central nervous system, gastrointestinal tract, respiratory epithelium, and immune tissues. In vitro studies in macrophage and immune cell line preparations have examined VIP’s receptor binding characteristics and cAMP-mediated downstream signalling at VPAC1 and VPAC2, documenting VIP-mediated modulation of cytokine expression profiles (including inhibition of endotoxin-induced pro-inflammatory cytokine production) through cAMP-dependent receptor-mediated signalling cascades in immune cell preparations [1]. In vivo rodent studies have investigated VIP across circadian biology, gastrointestinal motility, and neuroimmune interaction models, with published research documenting VIP’s role in suprachiasmatic nucleus circadian rhythmicity and intercellular synchrony among SCN clock neurons, characterising VIP-VPAC2 receptor signalling as a critical mechanism for the coordination of circadian timekeeping within the suprachiasmatic nucleus under controlled preclinical conditions [2], making VIP a key reference compound in neuropeptide research examining VPAC receptor-mediated signalling across neuroimmune and circadian biology models.

VIP is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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