Kisspeptin (CAS 374683-28-0), also referred to as Kisspeptin-10 or Metastin (45-54), is a synthetic decapeptide with the molecular formula C63H83N17O14 and a molecular weight of 1302.45 g/mol. Defined by the amino acid sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, Kisspeptin-10 corresponds to the C-terminal 10-amino acid fragment of the full-length 54-amino acid kisspeptin (Metastin), the minimal sequence required for receptor activation. The C-terminal Arg-Phe-NH2 amidated motif is considered critical to its binding at the kisspeptin receptor, GPR54 (also designated KISS1R). Produced via solid-phase peptide synthesis.

Kisspeptin-10 has been extensively investigated as a key research compound in the study of the hypothalamic-pituitary-gonadal (HPG) axis, where the KISS1/GPR54 signalling system has been characterised in published research as a critical upstream regulator of gonadotropin-releasing hormone (GnRH) neuron activity. In vitro studies in GPR54-expressing cell-based preparations have examined Kisspeptin-10 binding at GPR54/KISS1R and downstream Gq/11-coupled signalling, documenting phospholipase C activation and intracellular calcium mobilisation as primary readouts of kisspeptin-10-mediated receptor engagement and characterising the C-terminal decapeptide as a high-affinity ligand sufficient for Gq/11 activation in transfected cell preparations [1]. In vivo rodent studies have investigated the neuroendocrine consequences of central and peripheral Kisspeptin-10 administration, documenting LH and testosterone secretion responses following both central and peripheral kisspeptin-10 administration in rats and characterising kisspeptin-10 as a potent activator of the hypothalamic-pituitary-gonadal axis under controlled experimental conditions [2], making Kisspeptin-10 a key reference compound in HPG axis research examining GPR54/KISS1R-mediated neuroendocrine regulation of gonadotropin secretion.

Kisspeptin is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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