Buy Kisspeptin Research Peptide

Kisspeptin (CAS 374675-21-5), also referred to as Kisspeptin-10 or Metastin (45-54), is a synthetic decapeptide with the molecular formula C63H83N17O14 and a molecular weight of 1302.45 g/mol. Defined by the amino acid sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, Kisspeptin-10 corresponds to the C-terminal 10-amino acid fragment of the full-length 54-amino acid kisspeptin (Metastin), the minimal sequence required for receptor activation. The C-terminal Arg-Phe-NH2 amidated motif is considered critical to its binding at the kisspeptin receptor, GPR54 (also designated KISS1R).

Kisspeptin-10 has been extensively investigated as a key research compound in the study of the hypothalamic-pituitary-gonadal (HPG) axis, where the KISS1/GPR54 signaling system has been characterized in published research as a critical upstream regulator of gonadotropin-releasing hormone (GnRH) neuron activity. In vitro studies in GPR54-expressing cell-based preparations have examined the native 54-, 14-, and 13-amino acid kisspeptin isoforms binding at GPR54/KISS1R and downstream Gq/11-coupled signaling, documenting phospholipase C activation and intracellular calcium mobilization as primary readouts of receptor engagement across the isoform panel in transfected cell preparations [1]. In vivo rodent studies have investigated the neuroendocrine consequences of central and peripheral Kisspeptin-10 administration, documenting LH and testosterone secretion responses following both central and peripheral kisspeptin-10 administration in rats and characterizing kisspeptin-10 as a potent activator of the hypothalamic-pituitary-gonadal axis under controlled experimental conditions [2], making Kisspeptin-10 a key reference compound in HPG axis research examining GPR54/KISS1R-mediated neuroendocrine regulation of gonadotropin secretion.

Kisspeptin is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

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