CJC-1295 (No DAC) vs Sermorelin

How CJC-1295 (No DAC) and Sermorelin differ

CJC-1295 (No DAC) and Sermorelin are different molecules derived from the same parent, human growth hormone-releasing hormone (GHRH), a 44-residue hypothalamic hormone. Sermorelin is that hormone's N-terminal 29-residue fragment, and the names GRF(1-29) and GHRH(1-29) both refer to it. It carries no substitutions. CJC-1295 (No DAC) is built on the same 29-residue fragment, with four amino acid substitutions. It is also sold as Modified GRF(1-29), a name that states that construction more plainly. In the literature reviewed for Sermorelin, the overlapping name Mod GRF 1-29 is recorded as belonging to a molecule other than Sermorelin. Both compounds act at the pituitary GHRH receptor.

In the literature reviewed for CJC-1295 (No DAC), the pharmacokinetic findings, in rats and healthy volunteers, came from CJC-1295 with DAC, whose albumin-binding linker CJC-1295 (No DAC) lacks. CJC-1295 (No DAC) itself is essentially uncharacterized in humans.^[2] In the literature reviewed for Sermorelin, nothing transfers to CJC-1295 (No DAC). In an August 2026 PubMed search, most of the 331 records naming Sermorelin used it as a diagnostic reagent rather than as the compound under study.^[6]

CJC-1295 (No DAC) has no approval history of any kind. Saying sermorelin acetate is FDA approved is false, and saying it was never FDA approved is equally false. It held two US approvals, each for one indication: a diagnostic one in 1990 and a therapeutic one in 1997.^[3][4] Both were withdrawn at the sponsor's request, as of June 2009.^[3][4] Sermorelin's regulatory record belongs to Sermorelin alone and does not extend to CJC-1295 (No DAC). Sermorelin acetate was the active ingredient of prescription medicines, since withdrawn. The material supplied here is a research-grade preparation and is not one of those medicines.

CJC-1295 (No DAC) carries a D-alanine at position two, a single-position inversion; Sermorelin's backbone is ordinary L-configuration throughout. CJC-1295 (No DAC) contains no sulfur, so it carries neither methionine nor cysteine, and no disulfide or sulfoxide can form. Sermorelin contains a single methionine, which oxidizes to a sulfoxide on air exposure, and no cysteine.

Have CJC-1295 (No DAC) and Sermorelin been compared directly?

In the literature reviewed for CJC-1295 (No DAC), a rat study by Jette and colleagues compared the albumin-conjugated DAC form with hGRF(1-29). The literature reviewed for CJC-1295 (No DAC) does not state that comparator's C-terminal form. Results are reported for each compound in that model. The material Jette and colleagues identified as CJC-1295 was that conjugate, not the core sold as CJC-1295 (No DAC). No comparison of CJC-1295 (No DAC) with Sermorelin was found in a PubMed search run in October 2026.^[5] That search covers PubMed only.