Pure-TRZ-2 Research Peptide
Pure-TRZ-2 is a single peptide, a chain of 39 amino acids made in a laboratory, with a fatty-acid chain attached.
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Research Use Only · Not for human or veterinary consumption.
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What is Pure-TRZ-2?
Pure-TRZ-2 is a single peptide, a chain of 39 amino acids made in a laboratory, with a fatty-acid chain attached. It came out of an industry research program and appears in published research under its development code. It switches on the receptors for two of the body's own hormones, GIP and GLP-1. In cell tests it acted at the GIP receptor much as the body's own GIP does. At the GLP-1 receptor it favored one of the receptor's signals over another, and was weaker than the body's own GLP-1 at drawing the receptor into the cell. Detailed 3D maps of it attached to each receptor have been made with electron microscopes. It has been tested in cells and in mice, and studies in people have been published.
Pure-TRZ-2 Research & Reference
What Pure-TRZ-2 does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
Frequently Asked Questions
Is Pure-TRZ-2 third-party tested for purity?+−
Yes. Every batch of Pure-TRZ-2 is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
What does "Research Use Only" mean?+−
It means Pure-TRZ-2 is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals.
How is Pure-TRZ-2 shipped and stored?+−
Pure-TRZ-2 ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
What does "dual agonist" mean for Pure-TRZ-2?+−
An agonist is a molecule that switches a receptor on. Pure-TRZ-2 is a single peptide that activates two receptors, the ones for GIP and GLP-1, rather than a blend of two separate peptides. The LY3298176 Research article describes its activity at each receptor.
How does Pure-TRZ-2 differ from Pure-RTA-3?+−
Both are 39-amino-acid peptides with a C20 fatty-acid side chain attached through γ-glutamic acid, and both end in a C-terminal amide. Pure-TRZ-2 activates the GIP and GLP-1 receptors, while Pure-RTA-3 activates the glucagon receptor as well. In the chain, Pure-TRZ-2 has Aib at position 13 where Pure-RTA-3 has α-methyl-L-leucine, and it carries its side chain on lysine 20 with two AEEA spacers, where Pure-RTA-3 carries it on lysine 17 with one.
What part does the fatty-acid side chain play in its structure?+−
Lysine 20 carries a C20 fatty acid, joined to the chain through γ-glutamic acid and two AEEA spacers. A structural study using cryo-electron microscopy and computer simulations reported that this fatty-acid modification, together with the amino-acid sequence, shapes how the peptide acts at its two receptors.
GLP-1 & Incretin Research
Related Compounds
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99%
>99%
>99%