Tesamorelin (CAS 218949-48-5), also known as ThGRF(1-44)NH2, is a synthetic 44-amino acid analogue of full-length human growth hormone-releasing hormone (GHRH). With a molecular weight of 5135.86 g/mol, Tesamorelin is distinguished by the conjugation of a trans-3-hexenoic acid group to the tyrosine residue at the N-terminus, a structural modification that confers increased resistance to enzymatic degradation. Produced via solid-phase peptide synthesis, Tesamorelin acts at the GHRH receptor (GHRH-R) and is the only full-length GHRH analogue in this compound class to carry a lipid-modified N-terminal residue.

Tesamorelin occupies a distinctive position in preclinical endocrinology research as a stabilised full-length GHRH(1-44) analogue. Unlike the truncated GRF(1-29) analogues such as Sermorelin and CJC-1295, ThGRF(1-44)NH2 retains the complete 44-residue sequence of native GHRH, with the trans-3-hexenoic acid modification serving to resist dipeptidyl peptidase-IV (DPP-IV) cleavage at the N-terminus. In vitro receptor pharmacology studies in rat adenopituitary membrane preparations have examined binding characteristics and adenylate cyclase stimulation profiles of GRF analogues at the GHRH-R, characterising structural determinants of receptor engagement across full-length and truncated GRF analogue classes [1]. Published non-clinical studies in Sprague-Dawley rat and canine models have investigated Tesamorelin-mediated somatotropic axis activity, documenting GH and IGF-1 axis dynamics under controlled preclinical conditions [2], making ThGRF(1-44)NH2 a key reference compound in full-length GHRH analogue research.

Tesamorelin is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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