DNSP-11 (Dopamine Neuron Stimulating Peptide-11) is a synthetic C-terminal amidated 11-amino acid peptide with an molecular weight of 1180.27 g/mol. Defined by the amino acid sequence Pro-Pro-Glu-Ala-Pro-Ala-Glu-Asp-Arg-Ser-Leu-NH2 (PPEAPAEDRSL-NH2), DNSP-11 is derived from the proprotein domain of human glial cell line-derived neurotrophic factor (GDNF). The peptide corresponds to a predicted endopeptidase cleavage product from the GDNF pro-sequence, flanked by dibasic processing sites. Its sequence is highly conserved across human, rat, and mouse GDNF proprotein sequences. Produced via solid-phase peptide synthesis, DNSP-11 is associated with dopaminergic neuron survival and ERK1/2 signalling pathways in preclinical Parkinson’s disease research.

DNSP-11 is a small GDNF pro-domain-derived peptide that retains neurotrophic-like properties in dopaminergic cell populations but without requiring the GFRalpha1 receptor complex that mediates canonical GDNF signalling. Published in vitro studies have documented that DNSP-11 increases the survival and neurite outgrowth of cultured embryonic ventral mesencephalic dopaminergic neurons, reduces cytochrome c release and maintains mitochondrial integrity in dopaminergic cell lines, and that it does not bind the GFRalpha1 co-receptor [1], and that DNSP-11 exposure increases ERK1/2 phosphorylation in dopaminergic MN9D cells to levels comparable with GDNF [2]. In vivo rodent studies have investigated DNSP-11 in 6-hydroxydopamine (6-OHDA) lesion models of Parkinson’s disease, with published research documenting that repeated administration of DNSP-11 in the 6-OHDA rat model was associated with changes in striatal dopamine turnover, sparing of tyrosine-hydroxylase-positive neurons, and reduced amphetamine-induced rotational behaviour [3], making DNSP-11 a reference compound in preclinical neuroscience research examining GDNF pro-domain-derived peptide modulation of dopaminergic neuron survival and nigrostriatal function in rodent models.

DNSP-11 is manufactured in a cGMP compliant, ISO9001 certified laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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