Bronchogen, also known by its tetrapeptide designation AEDL (Ala-Glu-Asp-Leu), is a synthetic tetrapeptide bioregulator with the molecular formula C18H30N4O9 and a molecular weight of 446.45 g/mol. Developed at the Saint Petersburg Institute of Bioregulation and Gerontology as part of the Khavinson peptide bioregulator series, Bronchogen was designed based on peptide fractions isolated from murine bronchial mucosa. Its sequence, Ala-Glu-Asp-Leu, extends the AED core motif with a C-terminal leucine residue. The AEDL sequence has been the subject of biophysical studies examining its interaction with DNA, with published research reporting binding at guanine N7 sites within the major groove without visible distortion of the double helix structure. Produced via solid-phase peptide synthesis, Bronchogen is associated with bronchial epithelial gene expression and pulmonary tissue signalling pathways.

Bronchogen is an organ-specific tetrapeptide bioregulator within the Khavinson framework. A dedicated in vitro study has documented Bronchogen-specific effects on bronchial epithelial gene expression: in cultured human bronchial epithelial cells, the tetrapeptide upregulated a panel of genes governing bronchial epithelial differentiation and alongside markers of epithelial functional activity [1]. At the molecular level, consistent with the proposed direct-to-DNA mode of action, biophysical work on the isolated peptide has documented that Bronchogen binds double-stranded DNA in the major groove at the guanine N7 position, forming a complex without visible distortion of the double-helix structure [2], making Bronchogen a reference compound in preclinical respiratory research examining bronchial epithelial differentiation and gene expression, peptide–DNA interaction at defined nucleotide sites, and organ-specific short-peptide regulation of pulmonary gene expression.

Bronchogen is manufactured in a cGMP compliant, ISO9001 certified laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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