Orexin B Research Peptide
Orexin B is a chain of 28 amino acids made by nerve cells in the hypothalamus.
- Purity
- >99%
- Verified
- Independent HPLC purity verification on every batch
- Cold chain
- Temperature-controlled packaging from lab to door
- Certificate
- Certificate of Analysis available on request for this batch
Multi-vial Discount Available
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Quality Guaranteed
Every batch is HPLC-tested to >99% purity. Certificate of Analysis available on request; MSDS available on request.
Certificate of Analysis Available on Request
Request this batch's certificate using your order number.
What is Orexin B?
Orexin B is a chain of 28 amino acids made by nerve cells in the hypothalamus. It is also called hypocretin-2, and most published work uses that name. It comes from the same starting protein as Orexin A, which is sold separately here, but the two are cut into different pieces and behave differently. Orexin B is a straight chain with no internal links, where Orexin A is folded and held by two bridges. There is also a laboratory-made version of Orexin B with two links swapped, and much of the work described as "OX2-selective" uses that version rather than this one.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
Orexin B Research & Reference
What Orexin B does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Safety Data Sheet
The safety data sheet for Orexin B is below as a PDF, in the 16-section GHS format covering identification, hazards, handling, storage and disposal.
Frequently Asked Questions
Is Orexin B independently tested for purity?+−
Yes. Every batch of Orexin B is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
What does "Research Use Only" mean?+−
It means Orexin B is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. Orexin B is legal to purchase in the United States for in vitro and non-clinical laboratory research. It carries no FDA approval or therapeutic indication for human use. Orexin B is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is Orexin B shipped and stored?+−
Orexin B ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
Is Orexin B selective for the OX2 receptor?+−
Not in the way the phrase is usually meant. The 400-fold OX2R selectivity widely quoted in this area was measured on [Ala11, D-Leu15]-orexin B, an engineered analogue carrying two residue substitutions, and the paper reporting it does not give a selectivity ratio for the native peptide. Published work on native Orexin B in rat brain slices reports one effect mediated by OX2 receptors and a second that runs through neither orexin receptor. The Published Research tab gives both studies.
Is Orexin B the same as Orexin A?+−
No. They are two peptides cut from the same precursor protein. Orexin A is 33 residues, folded, with two internal disulfide bridges and a modified N-terminus; Orexin B is 28 residues and linear. Published work reports different effects for the two in the same brain region, and in a wake-promotion comparison Orexin A was the more potent. Findings for one are not findings for the other.
Related Compounds
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