Orexin B Research Peptide
Orexin B is a chain of 28 amino acids made by nerve cells in the hypothalamus.
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Research Use Only · Not for human or veterinary consumption.
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Safety Data Sheet
In the 16-section GHS format covering identification, hazards, handling, storage and disposal.
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What is Orexin B?
Orexin B is a chain of 28 amino acids made by nerve cells in the hypothalamus. It is also called hypocretin-2, though most published work uses the name orexin. It comes from the same starting protein as Orexin A, which is sold separately here, but the two are cut into different pieces and behave differently. Orexin B is a straight chain with no internal links, where Orexin A is folded and held by two bridges. There is also a laboratory-made version of Orexin B with two of its links replaced, and much of the work described as "OX2-selective" uses that version rather than this one.
Product information reviewed by Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer · Reviewed
Orexin B Research & Reference
What Orexin B does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
Frequently Asked Questions
Is Orexin B third-party tested for purity?+−
Yes. Every batch of Orexin B is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
What does "Research Use Only" mean?+−
It means Orexin B is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. Orexin B is legal to purchase in the United States for in vitro and non-clinical laboratory research. It carries no FDA approval or therapeutic indication for human use. Orexin B is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is Orexin B shipped and stored?+−
Orexin B ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
Is Orexin B selective for the OX2 receptor?+−
Not in the way the phrase is usually meant. The 400-fold OX2R selectivity widely quoted in this area was measured on [Ala11, D-Leu15]-orexin B, an engineered analogue carrying two residue substitutions. Native Orexin B is a potent agonist at both orexin receptors, and in rats the increase in motor activity it caused after injection into the brain was blocked by an OX1 receptor antagonist. OX2R-mediated effects of the native peptide are also on record: in rat midbrain cultures its protection of dopamine neurons was abolished by an OX2R antagonist. The Orexin B research article gives the affinity figures and the midbrain culture study.
Is Orexin B the same as Orexin A?+−
No. They are two peptides cut from the same precursor protein. Orexin A is 33 residues, folded, with two internal disulfide bridges and a modified N-terminus; Orexin B is 28 residues and linear. Published work reports different effects for the two in the same brain region, and in a wake-promotion comparison Orexin A was the more potent. Findings for one are not findings for the other.
Cognitive & Neuropeptide Research
Related Compounds
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Reviewed for scientific accuracy
Dr. Martina Rossi, PhD
PhD, Université Grenoble Alpes · Scientific Contributor and Reviewer
Dr. Rossi's doctoral research at Université Grenoble Alpes examined the vascular functions of bone morphogenetic proteins. Her peer-reviewed work spans cell and molecular biology, vascular biology, and gene therapy, in journals including Cardiovascular Research, Scientific Reports, and Brain Sciences. She reviews Pure Peptides' product, reference, and research pages for scientific accuracy against the sources they cite.