Hexarelin (CAS 140703-51-1), also known as Examorelin, is a synthetic hexapeptide growth hormone secretagogue with the molecular formula C47H58N12O6 and a molecular weight of 887.05 g/mol. Its amino acid sequence, His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2, features a 2-methyl-D-tryptophan residue at position 2, a structural modification considered significant to its receptor binding characteristics and resistance to proteolytic degradation. Produced via solid-phase peptide synthesis, Hexarelin acts as an agonist at the ghrelin receptor (GHS-R1a) and is one of the most frequently cited secretagogues in preclinical endocrine and cardiovascular research.

Hexarelin occupies a notable position in preclinical research due to the breadth of biological pathways it has been investigated alongside. In vitro studies in receptor binding preparations using human brain and pituitary tissue have examined its binding affinity at the GHS-R1a receptor and its capacity to stimulate intracellular calcium mobilisation in pituitary cell lines, with published work characterising specific GHS-R1a binding parameters and investigating its resistance to enzymatic degradation relative to earlier secretagogues such as GHRP-6 [1]. Beyond the somatotropic axis, Hexarelin has also been investigated in rodent cardiovascular models, where researchers have examined its interaction with isolated cardiac and myocardial tissue preparations, documenting cardiac activity independent of GH-mediated pathways, an area of investigation that distinguishes it from most other compounds in the secretagogue class [2].

Hexarelin is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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