MGF (Mechano Growth Factor), also known as IGF-1 Ec, is a synthetic 24-amino acid peptide corresponding to the C-terminal E-domain of the insulin-like growth factor 1 Ec splice variant. With the molecular formula C121H200N42O39 and a molecular weight of 2867.26 g/mol, MGF is defined by the amino acid sequence Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys. In native physiology this peptide domain is generated by alternative splicing of the IGF-1 gene and is expressed in a mechano-sensitive manner following tissue strain. Produced via solid-phase peptide synthesis, Mechano Growth Factor is associated with IGF-1 receptor-related signalling pathways in preclinical research.

MGF has been extensively investigated in preclinical growth factor research as the isolated E-domain peptide of the IGF-1 Ec isoform. Unlike mature IGF-1 which consists of the 70-amino acid core protein, Mechano Growth Factor represents the splice-specific C-terminal extension characterised in published studies for its independent signalling properties. In vitro studies in C2C12 myoblast and satellite cell-derived preparations have examined MGF’s interaction with skeletal muscle-derived cell populations, documenting differential roles of the Ec E-peptide relative to mature IGF-1 in myoblast proliferation kinetics and differentiation timing [1]. Rodent model studies have examined the relationship between E-domain peptide presence and downstream cellular responses in skeletal muscle and neural tissue preparations, documenting differential activity across IGF-1 splice variants including the Ec isoform under controlled preclinical conditions [2], making Mechano Growth Factor a key reference compound in IGF-1 splice variant research across skeletal muscle and neural tissue models.

MGF is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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