Buy IGF-1 LR3 Research Protein
Supplied as a lyophilised powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.
Buy IGF-1 LR3 Research Protein
Supplied as a lyophilised powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA on Request
Every batch
Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
HPLC Verified
≥98% purity
Lyophilised
Powder format
Express Shipping
Cold-chain included
COA on Request
Every batch
Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
What is IGF-1 LR3?
IGF-1 LR3 is a lab-modified, long-acting version of IGF-1 (insulin-like growth factor 1). Its changes reduce binding to the proteins that normally limit IGF-1, giving researchers a tool to study extended IGF-1 signaling in muscle, fat and growing cells.
- A long-acting IGF-1 with an added sequence at one end
- Reduced binding to IGF-binding proteins gives it a much longer active life
- Studied in animal research for its effects on muscle signaling and satellite cells
- Investigated for its effects on IGF-1 signaling and metabolism
For research use only. Not approved for human therapeutic use.
IGF-1 LR3 (Long Arginine 3-IGF-1), also known as LR3-IGF-1 (CAS 946870-92-4), is a synthetic 83-amino acid protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). With a molecular weight of 9117.60 g/mol, IGF-1 LR3 differs from native IGF-1 in two key structural respects: an arginine substitution at position 3 in place of glutamic acid, and an additional 13-amino acid extension at the N-terminus. These modifications confer markedly reduced binding affinity for insulin-like growth factor-binding proteins (IGFBPs). Produced via solid-phase peptide synthesis, Long R3-IGF-1 acts as an agonist at the IGF-1 receptor (IGF-1R).
IGF-1 LR3 has been extensively investigated in preclinical cell biology and growth factor research. Its altered IGFBP binding profile has made Long Arginine 3-IGF-1 a key reference compound in studies examining IGF-1R-mediated signalling independently of IGFBP-dependent regulatory mechanisms. In vitro studies in L6 rat myoblast and fibroblast cell preparations have investigated Long Arginine 3-IGF-1’s receptor activation kinetics, characterising IGF-1R-mediated biological potency relative to native IGF-1 as a function of IGFBP secretion and receptor engagement [1]. In vivo guinea pig studies have examined the pharmacokinetic implications of reduced IGFBP binding, documenting reduced plasma IGF-I, IGF-II and IGF binding protein concentrations alongside organ-selective growth effects following LR3-IGF-1 infusion relative to endogenous IGF-I [2].
IGF-1 LR3 is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.
Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.
References
Scientific Review
Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer
Reviewed for scientific accuracy, 14 June 2026
Lyophilised powder: store at -20 °C or below, away from light and moisture. Once reconstituted in an appropriate laboratory diluent (e.g. sterile water, PBS, or assay buffer), store at 2–8 °C and use within the validated period for your protocol. Do not refreeze.
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Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis and MSDS available on request.