Growth Hormone Axis Research

Fragment 176-191 Research Peptide

Fragment 176-191 is a short chain copied from the tail end of human growth hormone, which is 191 links long in full.

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Research Use Only · Not for human or veterinary consumption.

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Fragment 176-191 research peptide, >99% purity by HPLC, CAS 66004-57-7, lyophilized powder for in-vitro laboratory research, Pure Peptides
>99% purityHPLC + MS-UPLC

Safety Data Sheet

In the 16-section GHS format covering identification, hazards, handling, storage and disposal.

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What is Fragment 176-191?

Fragment 176-191 is a short chain copied from the tail end of human growth hormone, which is 191 links long in full. The related product AOD-9604 is the same tail piece with its first link changed: a tyrosine where growth hormone has a phenylalanine. Both have been studied for what the tail end of growth hormone does to fat tissue, separately from what the whole hormone does to growth. Most of that work is in obese rats and mice, and AOD-9604 has also been tested for safety in placebo-controlled trials in adults.

Product information reviewed by Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer · Reviewed

Fragment 176-191 Research & Reference

What Fragment 176-191 does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.

Technical Specs

CAS Number66004-57-7
Molecular FormulaC78H123N23O22S2
Molecular Weight1,799.10 g/mol
SequencePhe-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Purity>99%
Physical FormLyophilized Powder
TestingHPLC + MS-UPLC
SKUFRAG176
Batch No.PP/FRG/062026

Labeled quantity is net peptide content, not gross salt weight.

Frequently Asked Questions

Is Fragment 176-191 third-party tested for purity?+

Yes. Every batch of Fragment 176-191 is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.

What does "Research Use Only" mean?+

It means Fragment 176-191 is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. Fragment 176-191 is legal to purchase in the United States for in vitro and non-clinical laboratory research. It carries no FDA approval or therapeutic indication for human use. Fragment 176-191 appears in section S2 of the WADA Prohibited List for competitive athletes, a separate consideration from its legal research status. Sold strictly for qualified research use, not human or veterinary administration.

How is Fragment 176-191 shipped and stored?+

Fragment 176-191 ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.

How is HGH Fragment 176-191 different from AOD-9604?+

AOD-9604 is Tyr-hGH(177-191): it substitutes a tyrosine for the phenylalanine that sits at position 176 of growth hormone. Fragment 176-191 is the unmodified peptide. The two have overlapping but separate published literature, and this site reports each one's findings on its own page. Note that most of the published fat-tissue studies used AOD-9604 or a related peptide beginning at residue 177, not Fragment 176-191 itself.

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Dr. Martina Rossi, PhD

Reviewed for scientific accuracy

Dr. Martina Rossi, PhD

PhD, Université Grenoble Alpes · Scientific Contributor and Reviewer

Dr. Rossi's doctoral research at Université Grenoble Alpes examined the vascular functions of bone morphogenetic proteins. Her peer-reviewed work spans cell and molecular biology, vascular biology, and gene therapy, in journals including Cardiovascular Research, Scientific Reports, and Brain Sciences. She reviews Pure Peptides' product, reference, and research pages for scientific accuracy against the sources they cite.

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