GHRP-2 research peptide, ≥98% purity by HPLC, CAS 158861-67-7, lyophilized powder for in-vitro laboratory research, Pure Peptides
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Supplied as a lyophilised powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.

817.99 g/mol≥98% (HPLC)158861-67-7

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What is GHRP-2?

GHRP-2 is a synthetic six-amino-acid peptide studied for how it tells the pituitary to release growth hormone. It works on the ghrelin receptor, the same receptor the natural hunger hormone uses, and is used in research as a tool for studying the growth-hormone system.

  • Studied in published research for how it prompts pituitary growth-hormone release
  • Acts on the ghrelin receptor, the same one natural hunger signals use
  • Investigated for combined effects with GHRH-type compounds
  • Studied in research on growth-hormone and IGF-1 signaling

For research use only. Not approved for human therapeutic use.

GHRP-2 (Growth Hormone Releasing Peptide-2), also referred to as Pralmorelin and KP-102, is an synthetic Growth Hormone Secretagogue with the molecular formula C₄₅H₅₅N₉O₆ and molecular weight 817.99 g/mol. GHRP-2 features a D-2-naphthylalanine side-chain at the position 2 of the amino acid chain, a characteristic feature that is considered critical for ligand recognition by the ghrelin receptor (GHS-R1a). Produced via solid-phase peptide synthesis, Pralmorelin (CAS 158861-67-7) is among the most widely referenced second-generation secretagogues in preclinical growth hormone research.

GHRP-2 has been extensively investigated in preclinical endocrinology and neuroendocrine pharmacology. In vitro studies conducted on primary cultured ovine and rat pituitary somatotroph cell lines have examined the signalling process of GHRP-2/Pralmorelin in the activation of its GHS-R1a receptor through intracellular production of cAMP, voltage-dependent activation of Ca+ channels, and involvement of distinct PKC and PKA pathways in the stimulation of GH secretion [1]. In vivo studies in rodents have examined the role of GHRP-2/KP-102 within the somatotropic pathway, with evidence suggesting that GHRP-2 acts synergistically with GHRH mechanisms during pulsatile GH secretion [2]. The replacement of D-Tryptophan residue present in previous generation peptide GHRP-6 with D-2-Naphthylalanine marks the difference in structure between GHRP-2 [3], and GHRP-6 and has made GHRP-2 a key reference compound in comparative studies within the growth hormone secretagogues class.

GHRP-2 is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature-controlled, monitored cold storage system to preserve compound integrity throughout the supply chain. Certificates of Analysis are available upon request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

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