Buy ARA-290 Research Peptide

ARA-290 (CAS 1208243-50-8), also known as Cibinetide, is a synthetic 11-amino acid peptide derived from the tissue-protective helix-B domain of erythropoietin (EPO). With the molecular formula C51H84N16O21 and a molecular weight of 1257.32 g/mol, ARA-290 is defined by the amino acid sequence pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser. Structurally, Cibinetide features an N-terminal pyroglutamyl residue and was rationally designed to retain the cytoprotective signaling properties of EPO while eliminating erythropoietic activity. Produced via solid-phase peptide synthesis, ARA-290 is one of the most studied non-erythropoietic EPO derivatives in preclinical research.

ARA-290 has been investigated in preclinical tissue protection and neuroimmunology research as a compound that dissociates erythropoietin (EPO)’s cytoprotective functions from its haematopoietic activity. The innate repair receptor through which it signals is selectively upregulated in injured or inflamed tissue, providing a degree of tissue-selective targeting that has been the subject of considerable research interest. In vivo and in vitro studies underpinning the design of the helix-B-derived peptides have documented that the pyroglutamate helix-B surface peptide (the structure corresponding to ARA-290) is non-erythropoietic both in vitro and in vivo while retaining tissue-protective, cytoprotective activity, including a dose-dependent renoprotective effect in a rodent model of renal ischemia-reperfusion injury, and have attributed this cytoprotection to signaling through the EPO receptor (EPOR)/beta-common-receptor (CD131) heterocomplex rather than the classical erythropoietic EPOR homodimer [1]. Preclinical rodent models of peripheral neuropathy have examined sensory signaling parameters following ARA-290 administration, documenting that ARA-290 produces long-term relief of neuropathic pain in a rat spared-nerve-injury model, coupled with suppression of the spinal microglial neuroinflammatory response, suggestive of a mechanistic link between the two [2], making ARA-290 a reference compound in tissue-protection and neuroimmunology research examining innate-repair-receptor-mediated cytoprotective and anti-inflammatory signaling in preclinical models.

ARA-290 is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 11 August 2026

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