Dihexa Research Peptide
Dihexa is a small synthetic molecule built from two amino acids with a fatty chain added at one end and a second chain at the other, designed so that it survives in the body and can cross into the brain.
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Research Use Only · Not for human or veterinary consumption.
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In the 16-section GHS format covering identification, hazards, handling, storage and disposal.
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What is Dihexa?
Dihexa is a small synthetic molecule built from two amino acids with a fatty chain added at one end and a second chain at the other, designed so that it survives in the body and can cross into the brain. Its starting point was angiotensin IV, a short natural chain, and it is a different substance from that with its own separate research. The paper behind the explanation of how it was thought to work was retracted by the journal that published it in April 2025, along with two papers on related compounds from the same laboratory. The findings below come from one study that has not been retracted, though that study carries its own unresolved expression of concern, and a more recent independent study found no effect at all in the model it tested.
Product information reviewed by Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer · Reviewed
Dihexa Research & Reference
What Dihexa does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
Frequently Asked Questions
Is Dihexa third-party tested for purity?+−
Yes. Every batch of Dihexa is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
What does "Research Use Only" mean?+−
It means Dihexa is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. Dihexa is legal to purchase in the United States for in vitro and non-clinical laboratory research. It carries no FDA approval or therapeutic indication for human use. Dihexa is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is Dihexa shipped and stored?+−
Dihexa ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
Is it true that research on Dihexa has been retracted?+−
Yes, in part. Three papers in the Journal of Pharmacology and Experimental Therapeutics were retracted in April 2025, and each also carries an expression of concern. One of them is the originating laboratory's only direct evidence that dihexa acts by activating the hepatocyte growth factor/c-Met system; the other two report the opposite direction of effect for related compounds built on the same scaffold. A separate 2013 paper describing the compound's development has not been retracted, but it carries its own expression of concern, issued in 2021, from the same journal. A 2024 study by an unconnected group found no effect in the model it tested. In 2025 another unconnected group reported that dihexa infused into the brain rescued working memory deficits in rats after repeated mild traumatic brain injury, and that an HGF/MET antagonist blocked that effect. The Dihexa research article reports the three retractions, the 2013 paper's expression of concern and the 2024 study.
Is research on angiotensin IV research on Dihexa?+−
No. Angiotensin IV is a natural six-residue peptide with its own literature. Dihexa was designed from a three-residue fragment of one of its analogues, with a fatty acid group added at one end and an amide extension at the other, and it is a different molecule. No angiotensin IV finding appears on this page.
Cognitive & Neuropeptide Research
Related Compounds
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Reviewed for scientific accuracy
Dr. Martina Rossi, PhD
PhD, Université Grenoble Alpes · Scientific Contributor and Reviewer
Dr. Rossi's doctoral research at Université Grenoble Alpes examined the vascular functions of bone morphogenetic proteins. Her peer-reviewed work spans cell and molecular biology, vascular biology, and gene therapy, in journals including Cardiovascular Research, Scientific Reports, and Brain Sciences. She reviews Pure Peptides' product, reference, and research pages for scientific accuracy against the sources they cite.