Dihexa Research Peptide
Dihexa is a small synthetic molecule built from two amino acids with a fatty chain added at one end and a second chain at the other, designed so that it survives in the body and can cross into the brain.
- Purity
- >99%
- Dispatch
- Dispatched next business day with cold-chain delivery
- Cold chain
- Temperature-controlled packaging from lab to door
- Certificate
- Certificate of Analysis available on request for this batch
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Ships Next Day
Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.
Quality Guaranteed
Every batch is HPLC-tested to >99% purity. Certificate of Analysis available on request; MSDS available on request.
Certificate of Analysis Available on Request
Request this batch's certificate using your order number.
What is Dihexa?
Dihexa is a small synthetic molecule built from two amino acids with a fatty chain added at one end and a second chain at the other, designed so that it survives in the body and can cross into the brain. Its starting point was angiotensin IV, a short natural chain, and it is a different substance from that with its own separate research. Three of the most cited papers on this compound were retracted by the journal that published them in April 2025, including the papers behind the explanation of how it was thought to work. The findings below come from one study that has not been retracted, though that study carries its own unresolved expression of concern, and a more recent independent study found no effect at all in the model it tested.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
Dihexa Research & Reference
What Dihexa does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Safety Data Sheet
The safety data sheet for Dihexa is below as a PDF, in the 16-section GHS format covering identification, hazards, handling, storage and disposal.
Frequently Asked Questions
Is Dihexa independently tested for purity?+−
Yes. Every batch of Dihexa is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
What does "Research Use Only" mean?+−
It means Dihexa is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. Dihexa is legal to purchase in the United States for in vitro and non-clinical laboratory research. It carries no FDA approval or therapeutic indication for human use. Dihexa is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is Dihexa shipped and stored?+−
Dihexa ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
Is it true that research on Dihexa has been retracted?+−
Yes, in part. Three papers in the Journal of Pharmacology and Experimental Therapeutics were retracted in April 2025, and each also carries an expression of concern. Between them they are the source of the hepatocyte growth factor and c-Met mechanism that this compound is usually described by, and that mechanism has not been independently replicated. A separate 2013 paper describing the compound's development has not been retracted, but it carries its own expression of concern, issued in 2021, from the same journal. A 2024 study by an unconnected group found no effect in the model it tested. The Published Research tab reports all of this.
Is research on angiotensin IV research on Dihexa?+−
No. Angiotensin IV is a natural six-residue peptide with its own literature. Dihexa was designed from a three-residue fragment of one of its analogues, with a fatty acid group added at one end and an amide extension at the other, and it is a different molecule. No angiotensin IV finding appears on this page.
Related Compounds
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