FOXO4-DRI (Proxofim) Research Peptide
FOXO4-DRI is a synthetic peptide built to clear senescent cells.
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Research Use Only · Not for human or veterinary consumption.
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Safety Data Sheet
In the 16-section GHS format covering identification, hazards, handling, storage and disposal.
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What is FOXO4-DRI (Proxofim)?
FOXO4-DRI is a synthetic peptide built to clear senescent cells. Those are worn-out cells that stop dividing but refuse to clear away, and they build up in tissue over time. The peptide is copied from a stretch of a human protein called FOXO4, then rebuilt in two ways. The residue order is reversed, and every residue is the mirror-image D form rather than the L form found in the body. That is what retro-inverso means. The point of the rebuild is that the enzymes which chop up ordinary peptides do not recognize the mirror image. A second, positively charged sequence is attached to help it cross cell membranes.
Product information reviewed by Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer · Reviewed
FOXO4-DRI (Proxofim) Research & Reference
What FOXO4-DRI (Proxofim) does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
Frequently Asked Questions
Is FOXO4-DRI (Proxofim) third-party tested for purity?+−
Yes. Every batch of FOXO4-DRI (Proxofim) is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
What does "Research Use Only" mean?+−
It means FOXO4-DRI (Proxofim) is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals.
How is FOXO4-DRI (Proxofim) shipped and stored?+−
FOXO4-DRI (Proxofim) ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
What does DRI mean?+−
D-Retro-Inverso. The peptide sequence is written in reverse order and every residue is the D enantiomer rather than the L form found in natural proteins. The two changes together are intended to present the side chains in a similar arrangement while making the molecule unrecognisable to the enzymes that break down ordinary peptides. That is the design rationale; no source cited in the FOXO4-DRI research article measures the resistance directly.
Is there published evidence against this compound?+−
Yes, and it is in the FOXO4-DRI research article. A 2023 study in Circulation cleared senescent cells by four different routes, one of which was this peptide, and reported that doing so worsened a lung blood-vessel disorder. The arms that used this peptide were in mice, where it brought on pulmonary hemodynamic changes and loss of pulmonary endothelial cells; the worsening seen in rats came from a different senolytic drug. Its authors conclude that eliminating senescent pulmonary endothelial cells may worsen pulmonary hemodynamics, and the journal ran an editorial on the finding in the same issue. Separately, a study in human cartilage cells removed the senescent cells successfully but did not improve the cartilage those cells went on to produce.
Metabolic & Cellular Research
Related Compounds
Reviewed for scientific accuracy
Dr. Martina Rossi, PhD
PhD, Université Grenoble Alpes · Scientific Contributor and Reviewer
Dr. Rossi's doctoral research at Université Grenoble Alpes examined the vascular functions of bone morphogenetic proteins. Her peer-reviewed work spans cell and molecular biology, vascular biology, and gene therapy, in journals including Cardiovascular Research, Scientific Reports, and Brain Sciences. She reviews Pure Peptides' product, reference, and research pages for scientific accuracy against the sources they cite.