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Research Use Only · Not for human or veterinary consumption.
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Safety Data Sheet
In the 16-section GHS format covering identification, hazards, handling, storage and disposal.
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What is ACE-031?
ACE-031 is not a peptide. It is a fusion protein. One part is the piece of the human activin receptor type IIB that normally sits outside the cell. That is joined to the tail section of a human antibody. Its international non-proprietary name is ramatercept. The receptor fragment still grabs the proteins the real receptor would have caught, so it works as a decoy, mopping them up before they reach muscle. One of those proteins is myostatin, sold separately here as GDF-8. Follistatin 344, also sold here, blocks the same protein another way.
Product information reviewed by Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer · Reviewed
ACE-031 Research & Reference
What ACE-031 does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Technical Specs
Frequently Asked Questions
Is ACE-031 third-party tested for purity?+−
Yes. Every batch of ACE-031 is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
What does "Research Use Only" mean?+−
It means ACE-031 is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. ACE-031 is legal to purchase in the United States for in vitro and non-clinical laboratory research. It has no FDA approval and no approved human use. ACE-031 is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is ACE-031 shipped and stored?+−
ACE-031 ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
Is ACE-031 a peptide?+−
No. ACE-031, international non-proprietary name ramatercept, is a dimeric fusion protein whose two polypeptide chains come to about 77,500 g/mol, with the attached sugars adding further mass. It joins the extracellular ligand-binding domain of the human activin receptor type IIB to the Fc region of human IgG1. Its CAS registry number is 1169766-01-1.
Why was development of ACE-031 discontinued?+−
A randomized, placebo-controlled trial was stopped after its second dose level. The published report gives the reason as potential safety concerns of epistaxis and telangiectasias, meaning nosebleeds and small dilated blood vessels. The same report states that no serious or severe adverse events occurred and that the efficacy signals it recorded were trends that did not reach statistical significance. The ACE-031 research article sets out all three findings with the citation.
What did the 2025 analysis of black-market ACE-031 find?+−
Fourteen products sold under the ACE-031 name were analyzed. Two contained no protein reactive to an ACVR2B antibody. The other twelve contained the full-length human activin receptor IIB rather than the Fc fusion protein the name refers to, which the authors confirmed with a protease that cleaves Fc fusions and could not cleave the products. Published results obtained with characterized ACE-031 are not evidence about material of that kind.
What is the difference between ACE-031, GDF-8 and Follistatin 344?+−
GDF-8, or myostatin, is the ligand: it limits muscle growth. ACE-031 is a soluble decoy receptor that traps it before it reaches the receptor. Follistatin 344 is a binding protein that also binds it. A decoy receptor and a binding protein are different mechanisms, so the three are sold and studied separately and results reported for one are not reported for another.
Metabolic & Cellular Research
Related Compounds
Reviewed for scientific accuracy
Dr. Martina Rossi, PhD
PhD, Université Grenoble Alpes · Scientific Contributor and Reviewer
Dr. Rossi's doctoral research at Université Grenoble Alpes examined the vascular functions of bone morphogenetic proteins. Her peer-reviewed work spans cell and molecular biology, vascular biology, and gene therapy, in journals including Cardiovascular Research, Scientific Reports, and Brain Sciences. She reviews Pure Peptides' product, reference, and research pages for scientific accuracy against the sources they cite.