AOD-9604 (CAS 221231-10-3), also known as Tyr-hGH Fragment 176-191, is a synthetic 16-amino acid peptide derived from the C-terminal region of human growth hormone (hGH). With the molecular formula C78H123N23O23S2 and a molecular weight of 1815.13 g/mol, AOD-9604 features a characteristic intramolecular disulfide bridge between Cys7 and Cys14. This oxidised disulfide configuration is the defining structural distinction between AOD-9604 and the linear (reduced) form of HGH Fragment 176-191. Produced via solid-phase peptide synthesis.

AOD-9604 has been investigated in preclinical metabolic and adipose tissue research as a structurally constrained derivative of the hGH C-terminal domain. The presence of the intramolecular disulfide bridge has been characterised in published structure-activity studies as conferring conformational rigidity, with researchers comparing the oxidised and reduced forms to characterise the role of disulfide bonding in receptor-independent signalling. In vitro studies in adipocyte-based experimental preparations have examined AOD-9604’s intracellular lipid metabolism pathways and beta-adrenergic receptor-mediated signalling, documenting lipolytic cascade activation and metabolic pathway engagement associated with the oxidised disulfide form of the hGH C-terminal domain [1]. In vivo studies in obese mouse models including beta-3 adrenergic receptor knockout strains have investigated body composition parameters and adipose tissue dynamics following AOD-9604 administration, with published research documenting lipid metabolism outcomes under repeated administration and characterising whether the compound’s metabolic activity operates through beta-3 adrenergic receptor-dependent or receptor-independent mechanisms by directly comparing responses in wild-type and beta-3 AR-deficient animals [2], making AOD-9604 a key reference compound in structure-activity research examining the role of disulfide bonding in hGH C-terminal domain metabolic activity.

AOD-9604 is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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