Buy AOD-9604 Research Peptide

AOD-9604 (CAS 221231-10-3), also known as Tyr-hGH Fragment 176-191, is a synthetic 16-amino acid peptide derived from the C-terminal region of human growth hormone (hGH). With the molecular formula C78H123N23O23S2 and a molecular weight of 1815.13 g/mol, AOD-9604 features a characteristic intramolecular disulfide bridge between Cys7 and Cys14. This oxidized disulfide configuration is the defining structural distinction between AOD-9604 and the linear (reduced) form of HGH Fragment 176-191.

AOD-9604 has been investigated in preclinical metabolic and adipose tissue research as a structurally constrained derivative of the hGH C-terminal domain. The presence of the intramolecular disulfide bridge has been characterized in published structure-activity studies as conferring conformational rigidity, with researchers comparing the oxidized and reduced forms to characterise the role of disulfide bonding in receptor-independent signaling. In vivo studies in obese Zucker rats have examined AOD-9604’s metabolic actions following daily oral dosing, documenting reduced body weight gain, increased adipose tissue lipolytic activity, and no adverse effect on insulin sensitivity, in contrast to intact hGH [1]. In vivo studies in obese mouse models including beta-3 adrenergic receptor knockout strains have investigated body composition parameters and adipose tissue dynamics following AOD-9604 administration, with published research documenting lipid metabolism outcomes under repeated administration and characterizing whether the compound’s metabolic activity operates through beta-3 adrenergic receptor-dependent or receptor-independent mechanisms by directly comparing responses in wild-type and beta-3 AR-deficient animals [2], making AOD-9604 a key reference compound in structure-activity research examining the role of disulfide bonding in hGH C-terminal domain metabolic activity.

AOD-9604 is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

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