P21 (P021) Research Peptide
P21, also written P021, is a small synthetic molecule.
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Research Use Only · Not for human or veterinary consumption.
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Certificates of Analysis
Every batch is tested by an independent laboratory before release.
Verify Batch. Lot-level COA, Batch DF/P21/062026. Check the batch number printed on your vial against the certificate below, which reports the tests run on it.
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What is P21 (P021)?
P21, also written P021, is a small synthetic molecule. Four of its parts are amino acids, copied from a short stretch of a natural human protein called CNTF, and the other two are chemical groups attached at each end: a small cap at one end and a rigid cage-shaped carbon group at the other. Those two additions make up a large share of the molecule, so calling it a peptide only tells part of the story. The published evidence is split: results are positive in cells and in several rodent models, while in a mouse model of a different disorder, tested by a group that includes the compound's patent holder, it worked in cells but not in the live animal.
Product information reviewed by Dr. Martina Rossi, PhD
Scientific Contributor and Reviewer · Reviewed
P21 (P021) Research & Reference
What P21 (P021) does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.
Technical Specs
Labeled quantity is net peptide content, not gross salt weight.
P21 (P021) Batch Results
Batch DF/P21/062026
- Laboratory
- Kovera Labs
- Certified
- August 13, 2026
- Sample
- 10 mg vial
- Report
- KVR-2026-7FD178
An independent laboratory, Kovera Labs, tested a sample from this batch. These are the results on its certificate.
Purity
Pass99.641%
RP-HPLC, C18 column, 214 nm
Identity
PassConfirmed
LC-MS
Purity is an HPLC figure: the main peak’s share of everything the detector recorded at one wavelength. It’s not a weight. What a purity figure counts →
Check it with the lab. Kovera Labs’ verification page looks a certificate up by its report number. Product, batch, date and results should match this page.
Chromatogram
RP-HPLC · C18 · DAD 214 nm
Frequently Asked Questions
Is P21 (P021) third-party tested for purity?+−
Yes. Every batch of P21 (P021) is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.
Can I see the Certificate of Analysis before buying?+−
Yes. The Certificate of Analysis for the batch currently in stock can be viewed and downloaded directly on this page, before you place an order. Each certificate states the batch number, the measured purity, and the date of analysis, and can be verified independently with the issuing laboratory using the report number it carries.
What does "Research Use Only" mean?+−
It means P21 (P021) is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. P21 is legal to purchase in the United States for in vitro and non-clinical laboratory research. It has no FDA approval and no approved human use. P21 is not a scheduled substance under the Controlled Substances Act. Sold strictly for qualified research use, not human or veterinary administration.
How is P21 (P021) shipped and stored?+−
P21 (P021) ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.
Does P21 work by increasing BDNF?+−
That is the mechanism proposed by the laboratory that developed it, stated in its own paper as "probably via" increased BDNF expression lowering GSK3-beta activity. A 2024 study in a CDKL5 deficiency model, whose authors include the compound's patent holder, found that chronic treatment in Cdkl5 knockout mice failed to increase BDNF levels, though it corrected the same GSK3-beta pathway in the corresponding human cell model. The P21 research article reports the proposed BDNF mechanism and the 2024 mouse result, and does not choose between them.
How much of P21 is actually peptide?+−
Four of its components are amino acids: aspartate, glycine, glycine and leucine. The rest is an acetyl group at one end and an adamantyl group at the other, and at a molecular weight of 578.67 those two account for a substantial share of the molecule. Note also that the literature designation Ac-DGGLAG-NH2 does not mean the sequence ends in alanine and glycine: the "AG" denotes the adamantylated glycine cap.
Cognitive & Neuropeptide Research
Related Compounds
>99%
>99%
>99%
>99%
Reviewed for scientific accuracy
Dr. Martina Rossi, PhD
PhD, Université Grenoble Alpes · Scientific Contributor and Reviewer
Dr. Rossi's doctoral research at Université Grenoble Alpes examined the vascular functions of bone morphogenetic proteins. Her peer-reviewed work spans cell and molecular biology, vascular biology, and gene therapy, in journals including Cardiovascular Research, Scientific Reports, and Brain Sciences. She reviews Pure Peptides' product, reference, and research pages for scientific accuracy against the sources they cite.