Vesugen, also known by its tripeptide designation KED (Lys-Glu-Asp), is a synthetic tripeptide bioregulator with a molecular weight of 390.39 g/mol. Developed at the Saint Petersburg Institute of Bioregulation and Gerontology as part of the Khavinson peptide bioregulator series, Vesugen was designed based on peptide fractions associated with vascular endothelial tissue. Its structure combines a basic lysine residue with two acidic residues (glutamic acid and aspartic acid), and like other Khavinson bioregulators, it is proposed to exert its biological activity through direct interaction with DNA rather than conventional cell surface receptor binding. Produced via solid-phase peptide synthesis, Vesugen is associated with vascular endothelial gene expression and cardiovascular signalling pathways.

Vesugen has been investigated as an organ-specific short peptide bioregulator within the Khavinson framework. Published in vitro studies have documented that the Vesugen tripeptide modulates proliferation- and senescence-associated gene and protein expression in vascular endothelial cells: in dissociated and organotypic endothelial cultures used as models of replicative senescence and of atherosclerosis/restenosis, KED was reported to increase expression of Ki-67, connexin-43 (Cx43), VEGF and SIRT1, to reduce p53, and to normalise endothelin-1 levels [1]. Consistent with the proposed direct-to-DNA mechanism, molecular-docking studies have placed Vesugen within the core promoter region of the MKI67 (Ki-67) gene, binding the minor groove via a CATC sequence motif, alongside observed effects on endothelial cell proliferation in cultures derived from young and old animals [2], making Vesugen a reference compound in preclinical vascular bioregulation research examining endothelial senescence, Ki-67-associated proliferative signalling, and short-peptide/DNA interaction models.

Vesugen is manufactured in a cGMP compliant, ISO9001 certified laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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