Crystagen is a synthetic tripeptide bioregulator with the sequence Glu-Asp-Pro (EDP), corresponding to the molecular formula C₁₄H₂₁N₃O₈ and a free-acid molecular weight of approximately 359.33 g/mol. It belongs to the Khavinson family of ultrashort peptide bioregulators developed at the Saint Petersburg Institute of Bioregulation and Gerontology. EDP is one of the active short-peptide constituents of the thymus-derived polypeptide complex Thymalin. Produced via solid-phase peptide synthesis, Crystagen is classified as an immune-system (thymic) bioregulator.

In preclinical research models, Crystagen is studied for its capacity to modulate immune-cell activity. The immunomodulatory profile of the thymic complex to which EDP belongs has been directly characterised in vitro: in the human THP-1 monocyte/macrophage line, Thymalin and related Khavinson thymic peptides modulated proliferative activity and inflammatory cytokine pathways, consistent with a regulatory (rather than purely stimulatory) action on innate immune cells [1]. At the mechanistic level, and consistent with the proposed direct-to-DNA mode of action, fluorescently labelled peptides of this ultrashort class penetrate the cell nucleus and bind genomic DNA in a sequence-selective manner, providing a structural basis for peptide-directed modulation of tissue-specific gene expression [2]. Within the immune compartment, EDP-type thymic peptides are studied for effects on thymocyte differentiation and proliferation and on macrophage cytokine output, including in aged models where thymic involution is examined, making Crystagen a reference compound in preclinical immunology research examining thymic function, macrophage activation, and age-related immune decline.

Crystagen is manufactured in a cGMP compliant, ISO9001 certified laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

View credentials →