Vilon, also known by its dipeptide designation KE (Lys-Glu), is a synthetic dipeptide bioregulator with the molecular formula C11H21N3O5 and a molecular weight of 275.30 g/mol. Defined by the amino acid sequence Lys-Glu (L-Lysyl-L-Glutamic acid), Vilon is the shortest peptide in the Khavinson bioregulator series and has been identified as corresponding to the 32-33 dipeptide fragment of the 49-amino acid thymic hormone thymopoietin. Its structure pairs a basic lysine residue with an acidic glutamic acid residue. Produced via solid-phase peptide synthesis.

Vilon has been investigated in preclinical immunology as an ultra-short peptide bioregulator, with published research characterising a proposed mechanism of gene-expression modulation through direct DNA interaction rather than cell surface receptor binding. Published research examining the Lys-Glu dipeptide in human somatic cell preparations has characterised Vilon, alongside the tetrapeptide epitalon, as a proposed regulator of the expression of the ageing-associated genes CCL11 (eotaxin) and HMGB1 (alarmin), documenting these molecular markers as candidate readouts of dipeptide-mediated gene-expression modulation [1]. In vivo rodent studies have investigated the KE dipeptide in long-term ageing protocols, with published research documenting that chronic administration of the Lys-Glu dipeptide inhibited the growth of spontaneous tumours and increased life span in mice, characterising Vilon as a geroprotective agent across an extended-observation ageing protocol [2], making Vilon a key reference compound in peptide bioregulator research examining ultra-short dipeptide modulation of gene expression and gerontological endpoints in preclinical models.

Vilon is manufactured in a cGMP compliant laboratory to a guaranteed purity of 98% or above. Every batch is independently tested using HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Editorial Team

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed and approved 14 June 2026

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