Where can I buy PNC-27 online?

PNC-27 is available to purchase online from Pure Peptides for laboratory research use. Every order ships from US stock with a batch-specific Certificate of Analysis and cold-chain packaging included.

Is PNC-27 for sale to individual researchers, or only institutions?

PNC-27 is for sale to any qualified researcher or laboratory purchasing for in-vitro research purposes. Pure Peptides does not require institutional affiliation to place an order, though purchasers are responsible for ensuring their use complies with applicable regulations.

What are the molecular weight and CAS number of PNC-27?

PNC-27 is a synthetic peptide with a molecular weight of ~3,500–3,800 g/mol and CAS number N/A (novel chimeric research peptide). It is supplied as a lyophilized powder, with these specifications confirmed on the batch-specific Certificate of Analysis.

How do I order PNC-27 for my lab?

Simply select the quantity you require on this page and complete checkout. Orders placed before noon EST on business days are typically fulfilled and shipped the same business day from US stock.

How should PNC-27 be stored?

Store lyophilized PNC-27 at -20°C or below in a dry, dark environment. Once reconstituted for in-vitro use, prepare only the volume required for your assay and follow your institutional protocol for reconstituted reagent handling. Minimize freeze-thaw cycles to preserve stability.

How is PNC-27 reconstituted for in-vitro research?

For in-vitro research, PNC-27 is reconstituted with a laboratory-appropriate diluent such as sterile PBS, assay buffer, or another protocol-appropriate solvent, preparing only the volume required for your assay. Pure Peptides cannot advise on dosing, administration, or research methodology; all compounds are supplied for in-vitro laboratory use only.

Does PNC-27 come with a Certificate of Analysis?

Every batch of PNC-27 is independently tested by a third-party laboratory using HPLC and MS-UPLC analysis, confirming a guaranteed purity of ≥98%. The batch-specific Certificate of Analysis is available on request using your order number or batch lot number.

How quickly will my PNC-27 order ship?

Orders placed before noon EST on business days are typically fulfilled and shipped the same business day from US stock. All orders include cold-chain packaging and full shipment tracking.

PNC-27 research peptide, ≥98% purity by HPLC, CAS N/A (novel chimeric research peptide), lyophilized powder for in-vitro laboratory research, Pure Peptides

HPLC Verified

Buy PNC-27 Research Peptide

Name: PNC-27
Brand: Pure Peptides
SKU: RSC-PNC27-6727
Price: 109.50 USD
Availability: OutOfStock

Supplied as a lyophilised powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.

~3,500–3,800 g/mol≥98% (HPLC)N/A (novel chimeric research peptide)

HPLC Verified

Supplied as a lyophilised powder and independently verified to ≥98% purity by HPLC and MS-UPLC analysis.

CategoryMetabolic & Cellular Research

HPLC Verified

≥98% purity

Lyophilised

Powder format

Express Shipping

Cold-chain included

COA on Request

Every batch

Ships Next Day

Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.

HPLC Verified

≥98% purity

Lyophilised

Powder format

Express Shipping

Cold-chain included

COA on Request

Every batch

Ships Next Day

Orders confirmed before 12pm EST ship the same business day; orders after 12pm EST ship the next business day. Monday to Friday.

What is PNC-27?

PNC-27 is a synthetic peptide that joins a p53-derived sequence to a membrane-entering sequence. In lab studies it triggers cell death selectively in cell lines that carry high levels of a protein called HDM-2, while sparing cell lines without it. It is studied as a research tool for this selective cell-death pathway.

Built to trigger selective cell death in HDM-2-high cell lines in lab studies
Targets a protein found at high levels on certain cell lines, absent from control lines
Studied across several HDM-2-high cell lines in the lab
Used as a research tool for understanding HDM-2-related cell-death signaling

For research use only. Not approved for human therapeutic use.

PNC-27 is a synthetic chimeric peptide with a molecular weight of 4031.72 g/mol, consisting of a p53-derived HDM-2 (human double minute 2) binding domain fused to a cell-penetrating membrane-active sequence. The p53-derived segment corresponds to residues from the transactivation domain of the p53 tumour suppressor protein, the minimal region required for MDM2/HDM-2 binding, while the C-terminal membrane-active domain is designed to facilitate cellular membrane interaction. PNC-27 was designed based on the observation that HDM-2 is overexpressed and aberrantly localised to cell membranes in certain transformed cell populations. Produced via solid-phase peptide synthesis, PNC-27 is associated with MDM2/HDM-2 signalling and membrane integrity pathways.

PNC-27 is a peptide designed to exploit the differential membrane localisation of HDM-2 between normal and transformed cell populations. In vitro studies have documented that PNC-27 binds HDM-2 associated with the plasma membrane of cancer cells and kills them by membranolysis [1]. Structure-function studies have examined the relative contributions of the p53-derived binding domain and the membrane-active leader sequence: a foundational conformational-design study compared three p53-derived fragments and found all three selectively cytotoxic to transformed cells, while sparing normal cells and human cord-blood-derived stem cells [2], and subsequent work has characterised the resulting membrane pores as lined with PNC-27–HDM-2 complexes at approximately 1:1 stoichiometry, with pore formation and cell lysis dependent on membrane-localised HDM-2 expression [3], making PNC-27 a reference compound in preclinical oncology research examining p53-derived, HDM-2-directed membranolytic peptides and the differential membrane localisation of HDM-2 between transformed and normal cell populations.

PNC-27 is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available on request.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

References

1Sarafraz-Yazdi E, Bowne WB, Adler V, Sookraj KA, Wu V, Shteyler V, et al. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1918–23. ; PubMed Central PMCID: PMC2836618.PubMed PMID: 20080680 2Kanovsky M, Raffo A, Drew L, Rosal R, Do T, Friedman FK, et al. Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12438–43. ; PubMed Central PMCID: PMC60072.PubMed PMID: 11606716 3Sarafraz-Yazdi E, Mumin S, Cheung D, Fridman D, Lin B, Wong L, et al. PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. Biomedicines. 2022 Apr 20;10(5):945. ; PubMed Central PMCID: PMC9138867.PubMed PMID: 35625682

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 14 June 2026

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Batch-specific Certificate of Analysis available on request

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Every batch is HPLC-tested to ≥98% purity. Certificate of Analysis and MSDS available on request.

Buy PNC-27 Research Peptide

What is PNC-27?

What Researchers Say

Frequently Asked Questions

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NAD+

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