Buy Cortagen Research Peptide

Cortagen is a synthetic tetrapeptide bioregulator with the amino acid sequence Ala-Glu-Asp-Pro and a molecular weight of 430.4 g/mol. Developed at the Saint Petersburg Institute of Bioregulation and Gerontology as part of the Khavinson peptide bioregulator series, Cortagen was designed based on peptide fractions isolated from cerebral cortex tissue. Its structure pairs two acidic residues (glutamic acid and aspartic acid) with a proline residue, a conformationally constrained amino acid that introduces a characteristic backbone turn. Produced via solid-phase peptide synthesis, Cortagen is associated with central nervous system gene expression and cortical signaling pathways.

Cortagen has been investigated in preclinical neurobiology as part of the broader program of ultra-short peptide bioregulators developed by Professor Vladimir Khavinson. In common with related bioregulator peptides such as Pinealon (EDR), Epithalon (AEDG) and Cortexin, Cortagen has been proposed to exert its biological activity through direct interaction with DNA rather than conventional cell-surface receptor-mediated signaling. Published research has documented that microarray analysis of 15,247 transcripts in the heart of female CBA mice given Cortagen for five consecutive days identified 234 clones (1.53%) with significant expression changes, matching 110 known genes across multiple functional categories [1]. In vivo rodent studies have documented that Cortagen administration accelerates nerve regeneration, with administration after sciatic-nerve transection and suture increasing the growth rate and conduction velocity of regenerating fibers relative to untreated controls [2], making Cortagen a reference compound in preclinical neuroscience research examining ultra-short peptide-bioregulator modulation of gene expression and nervous-tissue parameters in rodent models.

Cortagen is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 11 August 2026

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