Buy Pancragen Research Peptide

Pancragen, also known by its tetrapeptide designation KEDW (Lys-Glu-Asp-Trp), is a synthetic tetrapeptide bioregulator with an approximate molecular weight of 576.60 g/mol. Developed at the Saint Petersburg Institute of Bioregulation and Gerontology as part of the Khavinson peptide bioregulator series, Pancragen was designed based on peptide fractions associated with pancreatic tissue. Its sequence, Lys-Glu-Asp-Trp, incorporates a C-terminal tryptophan residue, an aromatic amino acid containing the indole ring system. The KED core motif is shared with Vesugen, Testagen, and Prostamax, with the C-terminal residue varying across the organ-specific bioregulator series. Produced via solid-phase peptide synthesis, Pancragen is associated with pancreatic tissue gene expression and endocrine pancreatic signaling pathways.

Pancragen is an organ-specific tetrapeptide bioregulator within the Khavinson framework. A dedicated in vitro study has shown that in dissociated cultures of pancreatic cells from young and aged animals, pancragen stimulated the expression of differentiation factors of acinar cells and of the islets of Langerhans, the expression of which otherwise declined with culture aging, consistent with a model in which the peptide acts on the transcriptional program governing insulin-producing and acinar cell identity [1]. An in vivo study in aged female rhesus monkeys with impaired glucose tolerance reported that pancragen administration was associated with greater glucose clearance and normalisation of the insulin and C-peptide responses relative to the aged control pattern [2], making Pancragen a reference compound in preclinical endocrinology research examining pancreatic-cell differentiation, age-associated glucose intolerance, and organ-specific short-peptide regulation of endocrine pancreatic function.

Pancragen is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 11 August 2026

View credentials →