Immune & Thymic Research

Thymosin Alpha-1 Research Peptide

Thymosin Alpha-1 is a chain of 28 amino acids, first found in the thymus.

Thymosin Alpha-1 research peptide, >99% purity by HPLC, CAS 62304-98-7, lyophilized powder for in-vitro laboratory research, Pure Peptides
Purity
>99%
Dispatch
Dispatched next business day with cold-chain delivery
Cold chain
Temperature-controlled packaging from lab to door
Certificate
Certificate of Analysis available on request for this batch
$63.00

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Every batch is HPLC-tested to >99% purity. Certificate of Analysis available on request; MSDS available on request.

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What is Thymosin Alpha-1?

Thymosin Alpha-1 is a chain of 28 amino acids, first found in the thymus. That is the small gland behind the breastbone where immune cells learn to tell friend from foe. The compound carries a chemical cap at one end called an acetyl group. That cap is part of what it is: without it the chain weighs 42 units less and is a different substance. It is not Thymosin Beta-4, which is sold separately here and shares only the family name.

Technical Specs

CAS Number62304-98-7
Molecular FormulaC129H215N33O55
Molecular Weight3,108.31 g/mol
Purity>99%
Physical FormLyophilized Powder
TestingHPLC + MS-UPLC
SKUTA1
Batch No.DF/THY/092026

Labeled quantity is net peptide content, not gross salt weight.

Thymosin Alpha-1 Research & Reference

What Thymosin Alpha-1 does in published studies, and how to work with it in the laboratory, are covered in full on two dedicated pages rather than summarised here, so neither the evidence nor the handling detail is cut short.

Safety Data Sheet

The safety data sheet for Thymosin Alpha-1 is below as a PDF, in the 16-section GHS format covering identification, hazards, handling, storage and disposal.

Frequently Asked Questions

Is Thymosin Alpha-1 independently tested for purity?+

Yes. Every batch of Thymosin Alpha-1 is tested by an independent third-party laboratory using HPLC and MS-UPLC, confirming purity and mass identity before the batch is released. Pure Peptides does not test its own material.

What does "Research Use Only" mean?+

It means Thymosin Alpha-1 is supplied for in-vitro laboratory research and for no other purpose, and must not be administered to humans or animals. Thymosin Alpha-1 is legal to purchase in the United States for in vitro and non-clinical laboratory research. Thymosin Alpha-1 is not a scheduled substance under the Controlled Substances Act. As a medicine it is known as thymalfasin and marketed under the brand name ZADAXIN; it is authorised in more than 30 countries outside the United States and Europe, according to its developers, and it holds no marketing authorisation from the FDA, the UK MHRA, or, beyond a single orphan drug designation, the European Medicines Agency. The material supplied here is a research-grade preparation, not that licensed medicine, and it holds no marketing authorisation. Sold strictly for qualified research use, not human or veterinary administration.

How is Thymosin Alpha-1 shipped and stored?+

Thymosin Alpha-1 ships from US stock with cold-chain packaging and full tracking; orders placed before noon EST on business days are typically dispatched the same business day. On arrival, store the lyophilized powder at -20°C or below, dry and protected from light.

Is this the same as Thymosin Beta-4 or TB-500?+

No. Thymosin Alpha-1 is a 28-amino-acid peptide with an acetylated N-terminus. Thymosin Beta-4 is a separate 43-amino-acid peptide, and TB-500 is a fragment associated with it. They share a family name and nothing else. Research findings for one say nothing about the others.

What do the clinical trials show?+

They disagree. A 2025 double-blind phase 3 trial in 1,089 patients found 28-day mortality of 23.4% against 24.1% on placebo, with no difference on any secondary or safety outcome. A 2013 single-blind trial in 361 patients found 26.0% against 35.0%, at marginal significance that changes with the statistical test applied. A 2025 meta-analysis of 11 trials found a significant pooled effect that was no longer significant when restricted to high-quality or multicentre trials. The Published Research tab reports all three.

From the blog

Background and context on this compound.

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