Buy Thymosin Alpha-1 Research Peptide

Thymosin Alpha-1 (CAS 62304-98-7), also known as Thymalfasin, is a synthetic 28-amino acid peptide with the molecular formula C129H215N33O55 and a molecular weight of 3108.31 g/mol. Defined by the amino acid sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH, Thymalfasin features a characteristic N-terminal acetylation and is the most extensively characterized individual peptide within the thymosin family. Produced via solid-phase peptide synthesis, Thymalfasin signals through Toll-like receptors (TLRs) and is associated with T-cell maturation and innate immune signaling pathways in preclinical immunology research.

Thymosin Alpha-1 has been extensively investigated as one of the most widely studied thymic peptides in preclinical and translational immunology. In a published in vitro study, Thymosin Alpha-1 (Thymalfasin) induced functional maturation and interleukin-12 (IL-12) production in Aspergillus fumigatus-pulsed dendritic cells through a Toll-like receptor- and MyD88-dependent signaling pathway involving p38 MAPK/NF-κB activation [1]. In vivo mouse studies have investigated Thymalfasin/Thymosin α1 in immunological challenge models, including murine cytomegalovirus infection and cyclophosphamide-conditioned tumor models. These studies documented antiviral immune activation through TLR9/MyD88/IRF7-dependent pathways and IFN-α/IFN-γ responses [2], and, in a Lewis lung carcinoma model in C57Bl/6 mice, potentiation of interleukin-2 antitumour activity when Thymosin Alpha-1 and IL-2 were given together after cyclophosphamide; the response to that three-agent regimen was abolished by sub-lethal irradiation or by depletion of CD4/CD8 T cells or NK cells, whereas either immunomodulator alone was substantially less effective [3].

Thymosin Alpha-1 is produced to research-grade standards and independently verified by third-party HPLC and MS-UPLC analysis before dispatch. Vials are vacuum sealed and stored in a temperature controlled, monitored cold storage system. Certificates of Analysis are available to view and download directly on the product page.

Sold strictly for in vitro research purposes only. Not for human consumption. Intended for use by qualified researchers in laboratory settings only.

Scientific Review

Dr. Martina Rossi, PhD

Scientific Contributor and Reviewer

Reviewed for scientific accuracy, 11 August 2026

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